Department of Molecular, Cell and Systems Biology, University of California, Riverside, California, USA; email:
Annu Rev Microbiol. 2023 Sep 15;77:255-276. doi: 10.1146/annurev-micro-032521-041554. Epub 2023 Jun 2.
, the human malaria parasite, infects two hosts and various cell types, inducing distinct morphological and physiological changes in the parasite in response to different environmental conditions. These variations required the parasite to adapt and develop elaborate molecular mechanisms to ensure its spread and transmission. Recent findings have significantly improved our understanding of the regulation of gene expression in . Here, we provide an up-to-date overview of technologies used to highlight the transcriptomic adjustments occurring in the parasite throughout its life cycle. We also emphasize the complementary and complex epigenetic mechanisms regulating gene expression in malaria parasites. This review concludes with an outlook on the chromatin architecture, the remodeling systems, and how this 3D genome organization is critical in various biological processes.
疟原虫，人类疟疾的病原体，感染两种宿主和各种细胞类型，根据不同的环境条件，诱导寄生虫发生明显的形态和生理变化。这些变化要求寄生虫适应并发展出精细的分子机制，以确保其传播和传播。最近的发现极大地提高了我们对疟原虫基因表达调控的理解。在这里，我们提供了一个最新的综述，介绍了用于突出寄生虫在整个生命周期中发生的转录组调整的技术。我们还强调了调节疟原虫基因表达的互补和复杂的表观遗传机制。这篇综述以染色质结构、重塑系统以及这种 3D 基因组组织在各种生物过程中的关键作用为结论。
