Nanomaterial Research Laboratory (NMRL), Nano Division, Yenepoya Research Centre, Yenepoya (Deemed to Be University), Deralakatte, Mangalore, 575 018, India.
School of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, 4072, Australia.
Anal Chim Acta. 2023 Aug 8;1268:341430. doi: 10.1016/j.aca.2023.341430. Epub 2023 May 26.
Photoluminescent-carbon nanoparticles (PL-CNPs) are a new class of materials that received immense interest among researchers due to their distinct characteristics, including photoluminescence, high surface-to-volume ratio, low cost, ease of synthesis, high quantum yield, and biocompatibility. By exploiting these outstanding properties, many studies have been reported on its utility as sensors, photocatalysts, probes for bio-imaging, and optoelectronics applications. From clinical applications to point-of-care test devices, drug loading to tracking of drug delivery, and other research innovations demonstrated PL-CNPs as an emerging material that could substitute conventional approaches. However, some of the PL-CNPs have poor PL properties and selectivity due to the presence of impurities (e.g., molecular fluorophores) and unfavourable surface charges by the passivation molecules, which impede their applications in many fields. To address these issues, many researchers have been paying great attention to developing new PL-CNPs with different composite combinations to achieve high PL properties and selectivity. Herein, we thoroughly discussed the recent development of various synthetic strategies employed to prepare PL-CNPs, doping effects, photostability, biocompatibility, and applications in sensing, bioimaging, and drug delivery fields. Moreover, the review discussed the limitations, future direction, and perspectives of PL-CNPs in possible potential applications.
光致发光碳纳米粒子(PL-CNPs)是一类新型材料,由于其独特的特性,包括光致发光、高的比表面积、低成本、易于合成、高量子产率和生物相容性,在研究人员中引起了极大的兴趣。通过利用这些卓越的特性,已经有许多关于其在传感器、光催化剂、生物成像探针和光电子学应用方面的应用的研究报告。从临床应用到即时检测设备,从药物负载到药物输送的跟踪,以及其他研究创新,PL-CNPs 被证明是一种新兴的材料,可以替代传统的方法。然而,由于存在杂质(例如,分子荧光团)和钝化分子的不利表面电荷,一些 PL-CNPs 的光致发光性能和选择性较差,这阻碍了它们在许多领域的应用。为了解决这些问题,许多研究人员一直在关注开发具有不同复合组合的新型 PL-CNPs,以实现高的光致发光性能和选择性。本文全面讨论了制备 PL-CNPs 的各种合成策略、掺杂效应、光稳定性、生物相容性以及在传感、生物成像和药物输送领域的应用的最新进展。此外,该综述还讨论了 PL-CNPs 在可能的潜在应用中的局限性、未来方向和前景。