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巴西的利什曼病。第二十二篇:在内脏利什曼病于帕拉州圣塔伦爆发期间,从人、狗以及白蛉长须罗蛉(Lutzomyia longipalpis,Lutz & Neiva,1912)中分离出的利什曼原虫的特征

Leishmaniasis in Brazil. XXII: Characterization of Leishmania from man, dogs and the sandfly Lutzomyia longipalpis (Lutz & Neiva, 1912) isolated during an outbreak of visceral leishmaniasis in Santarém, Pará State.

作者信息

Braga R R, Lainson R, Shaw J J, Ryan L, Silveira F T

出版信息

Trans R Soc Trop Med Hyg. 1986;80(1):143-5. doi: 10.1016/0035-9203(86)90214-2.

DOI:10.1016/0035-9203(86)90214-2
PMID:3726975
Abstract

During epidemiological studies on an outbreak of visceral leishmaniasis in Santarém, Pará State, north Brazil, isolates of Leishmania from two children, three dogs and six naturally infected specimens of the sandfly Lutzomyia longipalpis were compared, biochemically, by starch-gel enzyme electrophoresis. They have proved to be indistinguishable from each other, and from a reference strain of Leishmania chagasi Cunha & Chagas, 1937 from a case of human visceral leishmaniasis from Bahia State, north-east Brazil, on their enzyme profiles for ASAT, ALAT, PGM, GPI, MDH and MPI. Lu. longipalpis is the principal, and possibly the only vector to man in the Amazon Region of Brazil.

摘要

在对巴西北部帕拉州圣塔伦市内脏利什曼病疫情进行的流行病学研究中,通过淀粉凝胶酶电泳对从两名儿童、三只狗以及六个自然感染的长须罗蛉沙蝇标本中分离出的利什曼原虫进行了生化比较。结果证明,这些分离株在天冬氨酸转氨酶(ASAT)、丙氨酸转氨酶(ALAT)、磷酸葡萄糖变位酶(PGM)、葡萄糖磷酸异构酶(GPI)、苹果酸脱氢酶(MDH)和磷酸甘露糖异构酶(MPI)的酶谱上,彼此之间以及与来自巴西东北部巴伊亚州一例人类内脏利什曼病病例的1937年查加斯利什曼原虫参考菌株没有区别。长须罗蛉沙蝇是巴西亚马逊地区人类利什曼病的主要传播媒介,可能也是唯一的传播媒介。

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