Kosiagin D V
Ukr Biokhim Zh (1978). 1986 May-Jun;58(3):65-8.
The protein/uronic acid ratio in monomers and aggregates of proteoglycans in the human articular cartilage is investigated. It is shown that for the first two hours of cartilage extraction by isotonic solution proteoglycans with the low concentration of chondroitin sulphate are mainly removed; in the process of the subsequent extraction proteoglycans with a large amount of chondroitin sulphate; the quantity of chondroitin sulphate in the molecule does not effect the ability of proteoglycans to aggregation. The protein/uronic acid ratio increases in cartilage proteoglycans with aging and in the process of cartilage degeneration due to a decrease in the amount of the carbohydrate part of the molecule.
对人关节软骨中蛋白聚糖单体和聚集体的蛋白质/糖醛酸比率进行了研究。结果表明，在等渗溶液提取软骨的前两小时，主要去除的是硫酸软骨素浓度低的蛋白聚糖；在随后的提取过程中，去除的是含有大量硫酸软骨素的蛋白聚糖；分子中硫酸软骨素的含量不影响蛋白聚糖的聚集能力。随着软骨老化以及在软骨因分子碳水化合物部分含量减少而发生退变的过程中，软骨蛋白聚糖的蛋白质/糖醛酸比率会升高。
