Goroshinskaia I A, Tsvetnenko E Z, Khodakova A A, Frenkel' M L, Gorkin V Z
Ukr Biokhim Zh (1978). 1986 May-Jun;58(3):74-7.
During hyperoxia monoamine oxidase type A acquires the ability to deaminate polyamines and histamine. A preliminary injection of clorgyline (a monoamine oxidase type A inhibitor) before hyperoxic exposure leads to a significant removal of oxygen seizures and prevents changes in the cerebral spermidine and histamine content observed in the unprotected animals. The data confirm the important role of modification of catalytic properties in monoamine oxidase in the mechanism of oxygen intoxication.
在高氧环境下，A型单胺氧化酶获得了使多胺和组胺脱氨基的能力。在高氧暴露前预先注射氯吉兰（一种A型单胺氧化酶抑制剂）可显著消除氧惊厥，并防止在未受保护的动物中观察到的脑内亚精胺和组胺含量的变化。这些数据证实了单胺氧化酶催化特性的改变在氧中毒机制中的重要作用。
