Goroshinskaia I A, Krichevskaia A A, Shugaleĭ V S, Sherstnev K B, Balamirzoeva R M
Vopr Med Khim. 1986 Mar-Apr;32(2):76-9.
Under conditions of hyperoxia mitochondrial monoamine oxidase (MAO) of the A type from rat brain proved to be able to deaminate gamma-aminobutyric acid (GABA); the transformation in the enzymatic properties appears to be responsible for a decrease in content of the intermediator in brain. Preadministration of chlorgiline (inhibitor of MAO of the A type) into animals before hyperoxygenation prevented completely the GABA content decrease, not affecting the glutamate decarboxylase activity, which was decreased in hyperoxia. At the same time, chlorgiline exhibited the total protective effect increasing 2-fold the period before oxygen convulsions.
在高氧条件下，大鼠脑内的A型线粒体单胺氧化酶（MAO）被证明能够使γ-氨基丁酸（GABA）脱氨；酶性质的转变似乎是导致脑内神经递质含量降低的原因。在动物进行高氧处理前预先给予氯吉兰（A型MAO抑制剂）可完全防止GABA含量降低，且不影响在高氧条件下降低的谷氨酸脱羧酶活性。同时，氯吉兰表现出全面的保护作用，使氧惊厥前的时间延长了2倍。
