Department of Obstetrics and Gynecology, National Clinical Research Center for Obstetric and Gynecologic Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Neurospine Center, Xuanwu Hospital, National Center for Neurological Disorders, China International Neuroscience Institute (CHINA-INI), Capital Medical University, Beijing, China.
BMC Womens Health. 2023 Jun 3;23(1):298. doi: 10.1186/s12905-023-02420-1.
Ovarian clear cell carcinoma (OCCC) is a distinct entity from epithelial ovarian cancer. The prognosis of advanced and recurrent disease is very poor due to resistance to chemotherapeutic agents. Our aim was to explore the molecular alterations among OCCC patients with different chemotherapeutic responses and to obtain insights into potential biomarkers.
Twenty-four OCCC patients were included in this study. The patients were divided into two groups based on the relapse time after the first-line platinum-based chemotherapy: the platinum-sensitive group (PS) and the platinum-resistant group (PR). Gene expression profiling was performed using NanoString nCounter PanCancer Pathways Panel.
Gene expression analysis comparing PR vs. PS identified 32 differentially expressed genes: 17 upregulated genes and 15 downregulated genes. Most of these genes are involved in the PI3K, MAPK and Cell Cycle-Apoptosis pathways. In particular, eight genes are involved in two or all three pathways.
The dysregulated genes in the PI3K, MAPK, and Cell Cycle-Apoptosis pathways identified and postulated mechanisms could help to probe biomarkers of OCCC platinum sensitivity, providing a research basis for further exploration of targeted therapy.
卵巢透明细胞癌（OCCC）是一种与上皮性卵巢癌不同的实体瘤。由于对化疗药物的耐药性，晚期和复发性疾病的预后非常差。我们的目的是探讨不同化疗反应的 OCCC 患者之间的分子改变，并获得对潜在生物标志物的深入了解。
本研究纳入了 24 名 OCCC 患者。根据一线铂类化疗后复发时间，将患者分为铂类敏感组（PS）和铂类耐药组（PR）。采用 NanoString nCounter PanCancer 通路面板进行基因表达谱分析。
PR 与 PS 比较的基因表达分析鉴定出 32 个差异表达基因：17 个上调基因和 15 个下调基因。这些基因大多参与 PI3K、MAPK 和细胞周期凋亡途径。特别是，有 8 个基因参与两个或所有三个途径。
鉴定出的 PI3K、MAPK 和细胞周期凋亡途径中失调的基因以及推测的机制有助于探索 OCCC 铂类敏感性的生物标志物，为进一步探索靶向治疗提供研究基础。
