Barna Andras Jozsef, Herold Zoltan, Acs Miklos, Bazsa Sandor, Gajdacsi Jozsef, Garay Tamas Marton, Herold Magdolna, Madaras Lilla, Muhl Dorottya, Nagy Akos, Szasz Attila Marcell, Dank Magdolna
Department of Obstetrics and Gynecology, Saint Pantaleon Hospital, H-2400 Dunaujvaros, Hungary.
Division of Oncology, Department of Internal Medicine and Oncology, Semmelweis University, H-1083 Budapest, Hungary.
Int J Mol Sci. 2023 Sep 5;24(18):13684. doi: 10.3390/ijms241813684.
Cancer-related immunity plays a significant role in the outcome of ovarian cancer, but the exact mechanisms are not fully explored. A retrospective, real-life observational study was conducted including 57 advanced ovarian cancer patients. Immunohistochemistry for CD4, CD8, and CD45 was used for assessing tumor-infiltrating immune cells. Furthermore, an immune-related gene expression assay was performed on 12-10 samples from patients with less than and more than 1-year overall survival (OS), respectively. A higher number of CD4 ( = 0.0028) and CD45 ( = 0.0221) immune cells within the tumor microenvironment were associated with longer OS of patients. In a multivariate setting, higher CD4 T cell infiltration predicted longer OS ( = 0.0392). Twenty-three differentially expressed genes-involved in antigen presentation, costimulatory signaling, matrix remodeling, metastasis formation, and myeloid cell activity-were found when comparing the prognostic groups. It was found that tumor-infiltrating immune cell counts are associated with peculiar gene expression patterns and bear prognostic information in ovarian cancer. expression emerged and was validated as a predictive marker for OS.
癌症相关免疫在卵巢癌的预后中起着重要作用，但确切机制尚未完全阐明。我们开展了一项回顾性、基于真实生活的观察性研究，纳入了57例晚期卵巢癌患者。采用CD4、CD8和CD45免疫组织化学方法评估肿瘤浸润免疫细胞。此外，分别对总生存期（OS）小于1年和大于1年的患者各12 - 10份样本进行了免疫相关基因表达检测。肿瘤微环境中CD4（P = 0.0028）和CD45（P = 0.0221）免疫细胞数量较多与患者较长的OS相关。在多变量分析中，较高的CD4 T细胞浸润预示着较长的OS（P = 0.0392）。在比较预后组时，发现了23个差异表达基因，这些基因涉及抗原呈递、共刺激信号传导、基质重塑、转移形成和髓样细胞活性。研究发现，肿瘤浸润免疫细胞计数与特定的基因表达模式相关，并在卵巢癌中具有预后信息。发现……表达出现并被验证为OS的预测标志物。 （注：原文中“expression emerged and was validated as a predictive marker for OS.”前似乎缺少关键信息）
