Department 1 of Internal Medicine, Center for Integrated Oncology Aachen, Bonn, Cologne, Düsseldorf, University Hospital of Cologne, Cologne, Germany.
Science and Research Center Koper, Institute for Kinesiology Research, Koper, Slovenia.
Eur J Appl Physiol. 2023 Oct;123(10):2271-2281. doi: 10.1007/s00421-023-05244-x. Epub 2023 Jun 4.
The present study investigated whether larger splenic emptying augments faster excess post-exercise O consumption (EPOC) following aerobic exercise cessation.
Fifteen healthy participants (age 24 ± 4, 47% women) completed 3 laboratory visits at least 48-h apart. After obtaining medical clearance and familiarizing themselves with the test, they performed a ramp-incremental test in the supine position until task failure. At their final visit, they completed three step-transition tests from 20 W to a moderate-intensity power output (PO), equivalent to [Formula: see text]O at 90% gas exchange threshold, where data on metabolic, cardiovascular, and splenic responses were recorded simultaneously. After step-transition test cessation, EPOC was recorded, and the first 10 min of the recovery period was used for further analysis. Blood samples were collected before and immediately after the end of exercise.
In response to moderate-intensity supine cycling ([Formula: see text]O = ~ 2.1 L·min), a decrease in spleen volume of ~ 35% (p = 0.001) was observed, resulting in a transient increase in red cell count of ~ 3-4% (p = 0.001) in mixed venous blood. In parallel, mean blood pressure, heart rate, and stroke volume increased by 30-100%, respectively. During recovery, mean τ[Formula: see text]O was 45 ± 18 s, the amplitude was 2.4 ± 0.5 L·min, and EPOC was 1.69 LO. Significant correlations were observed between the percent change in spleen volume and (i) EPOC (r = - 0.657, p = 0.008) and (ii) τ[Formula: see text]O (r = - 0.619, p = 0.008), but not between the change in spleen volume and (iii) [Formula: see text]O peak (r = 0.435, p = 0.105).
Apparently, during supine cycling, individuals with larger spleen emptying tend to have slower [Formula: see text] O recovery kinetics and a greater EPOC.
本研究旨在探讨运动后恢复期脾脏排空增加是否会加速有氧运动停止后的过量氧耗（EPOC）。
15 名健康参与者（年龄 24±4 岁，47%为女性）在至少相隔 48 小时的 3 个实验室访问中完成了研究。在获得医疗许可并熟悉测试后，他们在仰卧位进行斜坡递增测试，直到任务失败。在最后一次就诊时，他们从 20 W 进行了三次步阶过渡测试到中等强度的功率输出（PO），相当于 90%气体交换阈值时的[Formula: see text]O，同时记录代谢、心血管和脾脏反应的数据。步阶过渡测试停止后，记录 EPOC，并在恢复期间的前 10 分钟进行进一步分析。在运动结束前后采集血样。
在对中等强度的仰卧位自行车运动（[Formula: see text]O=~2.1 L·min）的反应中，脾脏体积减少了约 35%（p=0.001），导致混合静脉血中红细胞计数暂时增加了约 3-4%（p=0.001）。与此同时，平均血压、心率和心输出量分别增加了 30-100%。在恢复期间，平均τ[Formula: see text]O 为 45±18 s，幅度为 2.4±0.5 L·min，EPOC 为 1.69 LO。脾脏体积的百分比变化与（i）EPOC（r=-0.657，p=0.008）和（ii）τ[Formula: see text]O（r=-0.619，p=0.008）之间存在显著相关性，但与（iii）[Formula: see text]O 峰值之间没有相关性（r=0.435，p=0.105）。
显然，在仰卧位骑自行车时，脾脏排空较多的个体倾向于具有较慢的[Formula: see text]O 恢复动力学和更大的 EPOC。
