Department of Ophthalmology, Mie University Graduate School of Medicine, Tsu, Japan.
Department of Ophthalmology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
Ophthalmologica. 2023;246(3-4):219-226. doi: 10.1159/000531342. Epub 2023 Jun 2.
The aim of this study was to determine whether the use of perfluorocarbon liquid (PFCL) affects the rate of retinal re-attachments after an initial attachment by vitrectomy in eyes with rhegmatogenous retinal detachment (RRD).
This was a retrospective, observational, multicenter study of 3,446 eyes registered in the Japanese vitreoretinal surgery treatment information database. Of these, 2,648 eyes had undergone vitrectomy as the first surgery for RRD. The re-attachment rates after the primary vitrectomy with or without PFCL were evaluated. In addition, the significance of factors affecting the re-detachments was determined by univariate and multivariate analyses. The measured outcomes were the rates of re-attachments after the primary vitrectomy with or without the use of PFCL.
A total of 2,362 eyes in the database were analyzed: 325 had and 2,037 did not have PFCL injected into the vitreous cavity during the vitrectomy. The rate of re-attachments was 91.5% in the PFCL group and 93.2% in the non-PFCL group (p = 0.46, χ2 test). Although there were several risk factors associated with the re-detachments in eyes without PFCL (p < 0.05, Welch's t tests, and Fisher's exact tests), they were not associated in eyes with PFCL use. However, multivariate analyses showed that there was no significant association between the use and the non-use of PFCL in the rate of re-detachments (β = -0.08, p = 0.46).
The use of PFCL during the initial vitrectomy for RRD does not affect the rate of re-attachments.
本研究旨在确定在孔源性视网膜脱离（RRD）患者中，初次玻璃体切割术后使用全氟碳液体（PFCL）是否会影响视网膜再附着率。
这是一项回顾性、观察性、多中心研究，纳入了日本玻璃体视网膜手术治疗信息数据库中的 3446 只眼。其中 2648 只眼因 RRD 首次接受玻璃体切割术。评估了初次玻璃体切割术联合或不联合 PFCL 后的再附着率。此外，通过单因素和多因素分析确定了影响再脱离的因素的意义。测量的结果是初次玻璃体切割术联合或不联合使用 PFCL 后的再附着率。
数据库中共有 2362 只眼进行了分析：325 只眼在玻璃体切割术中注入了 PFCL，2037 只眼未注入。PFCL 组的再附着率为 91.5%，非-PFCL 组为 93.2%（p = 0.46，卡方检验）。尽管在未使用 PFCL 的眼中有几个与再脱离相关的风险因素（p < 0.05，Welch's t 检验和 Fisher 精确检验），但在使用 PFCL 的眼中没有关联。然而，多因素分析显示，在再脱离率方面，PFCL 的使用与不使用之间没有显著关联（β = -0.08，p = 0.46）。
在 RRD 的初次玻璃体切割术中使用 PFCL 不会影响再附着率。
