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A single measurement of fecal hemoglobin concentration outperforms polygenic risk score in colorectal cancer risk assessment.

作者信息

Niedermaier Tobias, Alwers Elizabeth, Chen Xuechen, Heisser Thomas, Hoffmeister Michael, Brenner Hermann

机构信息

Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Baden-Württemberg, Germany.

Medical Faculty Heidelberg, Heidelberg University, Heidelberg, Baden-Württemberg, Germany.

出版信息

Cancer Commun (Lond). 2023 Aug;43(8):947-950. doi: 10.1002/cac2.12448. Epub 2023 Jun 4.

DOI:10.1002/cac2.12448
PMID:37272255
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10397559/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c5d/10397559/0d6256cdf670/CAC2-43-947-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c5d/10397559/0d6256cdf670/CAC2-43-947-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c5d/10397559/0d6256cdf670/CAC2-43-947-g001.jpg

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本文引用的文献

1
Comparing the Cost-Effectiveness of Innovative Colorectal Cancer Screening Tests.比较创新型结直肠癌筛查测试的成本效益。
J Natl Cancer Inst. 2021 Feb 1;113(2):154-161. doi: 10.1093/jnci/djaa103.
2
Genome-wide Modeling of Polygenic Risk Score in Colorectal Cancer Risk.全基因组建模分析多基因风险评分在结直肠癌风险中的作用。
Am J Hum Genet. 2020 Sep 3;107(3):432-444. doi: 10.1016/j.ajhg.2020.07.006. Epub 2020 Aug 5.
3
External Validation of Risk Prediction Models Incorporating Common Genetic Variants for Incident Colorectal Cancer Using UK Biobank.
利用英国生物库对纳入常见遗传变异的结直肠癌发病风险预测模型进行外部验证。
Cancer Prev Res (Phila). 2020 Jun;13(6):509-520. doi: 10.1158/1940-6207.CAPR-19-0521. Epub 2020 Feb 18.
4
Cost-Effectiveness of Risk-Stratified Colorectal Cancer Screening Based on Polygenic Risk: Current Status and Future Potential.基于多基因风险的风险分层结直肠癌筛查的成本效益：现状与未来潜力
JNCI Cancer Spectr. 2019 Oct 14;4(1):pkz086. doi: 10.1093/jncics/pkz086. eCollection 2020 Feb.
5
Efficacy and cost-effectiveness of fecal immunochemical test versus colonoscopy in colorectal cancer screening: a systematic review and meta-analysis.粪便免疫化学试验与结肠镜检查在结直肠癌筛查中的疗效和成本效益：系统评价和荟萃分析。
Gastrointest Endosc. 2020 Mar;91(3):684-697.e15. doi: 10.1016/j.gie.2019.11.035. Epub 2019 Nov 30.
6
Changes in FIT values below the threshold of positivity and short-term risk of advanced colorectal neoplasia: Results from a population-based cancer screening program.低于阳性阈值的 FIT 值变化与结直肠高级别腺瘤近期风险：基于人群的癌症筛查项目研究结果。
Eur J Cancer. 2019 Jan;107:53-59. doi: 10.1016/j.ejca.2018.11.004. Epub 2018 Dec 10.
7
Factors associated with false-positive fecal immunochemical tests in a large German colorectal cancer screening study.在一项大型德国结直肠癌筛查研究中，与粪便免疫化学检测假阳性相关的因素。
Int J Cancer. 2019 May 15;144(10):2419-2427. doi: 10.1002/ijc.31972. Epub 2019 Jan 4.
8
Direct Comparison of Diagnostic Performance of 9 Quantitative Fecal Immunochemical Tests for Colorectal Cancer Screening.9 种用于结直肠癌筛查的定量粪便免疫化学检测方法的诊断性能直接比较。
Gastroenterology. 2018 Jan;154(1):93-104. doi: 10.1053/j.gastro.2017.09.018. Epub 2017 Sep 25.
9
Baseline faecal occult blood concentration as a predictor of incident colorectal neoplasia: longitudinal follow-up of a Taiwanese population-based colorectal cancer screening cohort.基线粪便潜血浓度作为结直肠新生物的预测因子：基于人群的台湾结直肠癌筛查队列的纵向随访。
Lancet Oncol. 2011 Jun;12(6):551-8. doi: 10.1016/S1470-2045(11)70101-2. Epub 2011 May 16.
10
Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach.比较两条或多条相关的受试者工作特征曲线下的面积：一种非参数方法。
Biometrics. 1988 Sep;44(3):837-45.