甲型肝炎病毒感染后持续性胆汁淤积：病例报告及文献综述
Prolonged Cholestasis Following Acute Hepatitis A Infection: Case Report and a Review of Literature.
作者信息
Alebaji Mohamad B, Mehair Alaa S, Shahrour Ola I, Elkhatib Feryal A, Alkaabi Eiman H, Alkuwaiti Najla S
机构信息
Pediatric Medicine, Tawam Hospital, Abu Dhabi, ARE.
出版信息
Cureus. 2023 May 3;15(5):e38511. doi: 10.7759/cureus.38511. eCollection 2023 May.
Abstract
Prolonged cholestasis is a rare complication of hepatitis A infection, characterized by a protracted, indolent course with persistent symptoms of pruritus and malabsorption lasting for several months. A 14-year-old girl, previously treated for acute hepatitis A, presented with yellowing of the eyes. An evaluation of her liver function revealed conjugated hyperbilirubinemia, and a liver biopsy confirmed hepatitis with cholestasis. Fortunately, she responded well to conservative treatment and recovered successfully.
摘要
长期胆汁淤积是甲型肝炎感染的一种罕见并发症，其特点是病程迁延、进展缓慢，伴有持续数月的瘙痒和吸收不良等症状。一名曾接受过甲型肝炎急性期治疗的14岁女孩出现了眼睛发黄的症状。对其肝功能的评估显示结合胆红素血症，肝脏活检证实为伴有胆汁淤积的肝炎。幸运的是，她对保守治疗反应良好，最终成功康复。
相似文献
1
Prolonged Cholestasis Following Acute Hepatitis A Infection: Case Report and a Review of Literature.甲型肝炎病毒感染后持续性胆汁淤积：病例报告及文献综述
Cureus. 2023 May 3;15(5):e38511. doi: 10.7759/cureus.38511. eCollection 2023 May.
2
Prolonged cholestasis after acute viral hepatitis: successfully treated with oral steroid.急性病毒性肝炎后迁延性胆汁淤积：口服类固醇治疗成功。
BMJ Case Rep. 2020 May 21;13(5):e234430. doi: 10.1136/bcr-2020-234430.
3
Hepatobiliary complications of oral contraceptives.口服避孕药的肝胆并发症。
J Gen Intern Med. 1992 Mar-Apr;7(2):199-209. doi: 10.1007/BF02598014.
4
Kawasaki Disease With Combined Cholestatic Hepatitis and Infection: A Case Report and Literature Review.川崎病合并胆汁淤积性肝炎及感染：病例报告与文献综述
Front Pediatr. 2022 Feb 9;9:738215. doi: 10.3389/fped.2021.738215. eCollection 2021.
5
Ticlopidine-induced prolonged cholestasis: a case report.噻氯匹定引起的长期胆汁淤积：一例报告
Eur J Gastroenterol Hepatol. 1999 Jun;11(6):673-6. doi: 10.1097/00042737-199906000-00015.
6
Successful treatment of prolonged cholestasis following hepatitis A infection in a child with oral steroid therapy.一例口服类固醇治疗患儿甲型肝炎感染后迁延性胆汁淤积的成功治疗。
BMJ Case Rep. 2023 Dec 9;16(12):e257477. doi: 10.1136/bcr-2023-257477.
7
[Acute hepatitis C infection with prolonged intrahepatic cholestasis and remarkable progression of fibrosis mimicking fibrosing cholestatic hepatitis].[急性丙型肝炎感染伴肝内胆汁淤积持续时间延长及纤维化显著进展，酷似纤维性胆汁淤积性肝炎]
Nihon Shokakibyo Gakkai Zasshi. 2014 Jun;111(6):1141-8.
8
Hemoadsorption in isolated conjugated hyperbilirubinemia after extracorporeal membrane oxygenation support. Cholestasis of sepsis: A case report and review of the literature on differential causes of jaundice in ICU patient.体外膜肺氧合支持后孤立性结合胆红素血症的血液吸附。脓毒症性胆汁淤积：1例病例报告及关于ICU患者黄疸不同病因的文献综述
Int J Artif Organs. 2019 May;42(5):263-268. doi: 10.1177/0391398819834012. Epub 2019 Mar 28.
9
Prolonged intrahepatic cholestasis secondary to acute hepatitis A.急性甲型肝炎继发的长期肝内胆汁淤积
Ann Intern Med. 1984 Nov;101(5):635-7. doi: 10.7326/0003-4819-101-5-635.
10
Benign Recurrent Intrahepatic Cholestasis Type 2 in Siblings with Novel Mutations.携带新型突变的兄弟姐妹中的2型良性复发性肝内胆汁淤积症
Pediatr Gastroenterol Hepatol Nutr. 2019 Mar;22(2):201-206. doi: 10.5223/pghn.2019.22.2.201. Epub 2019 Feb 27.
引用本文的文献
1
Therapeutic Options for the Management of the Cholestatic Phase of Viral Hepatitis A and E-A Systematic Review.甲型和戊型病毒性肝炎胆汁淤积期管理的治疗选择——一项系统评价
J Clin Exp Hepatol. 2025 Sep-Oct;15(5):102557. doi: 10.1016/j.jceh.2025.102557. Epub 2025 Mar 24.
2
Zoonotic and Food-Related Hazards Due to Hepatitis A and E in Africa: A Systematic Review and Meta-Analysis.非洲甲型和戊型肝炎所致人畜共患及与食物相关的危害：一项系统评价与荟萃分析
Environ Health Insights. 2024 Nov 21;18:11786302241299370. doi: 10.1177/11786302241299370. eCollection 2024.
3
Hepatitis A virus infection.甲型肝炎病毒感染
Nat Rev Dis Primers. 2023 Sep 28;9(1):51. doi: 10.1038/s41572-023-00461-2.
本文引用的文献
1
Hepatitis A: Epidemiology, High-Risk Groups, Prevention and Research on Antiviral Treatment.甲型肝炎：流行病学、高危人群、预防和抗病毒治疗研究。
Viruses. 2021 Sep 22;13(10):1900. doi: 10.3390/v13101900.
2
Hepatitis A virus knowledge and immunization attitudes and practices in the United Arab Emirates community.阿联酋社区的甲型肝炎病毒知识、免疫态度和实践。
Sci Rep. 2021 Jan 29;11(1):2651. doi: 10.1038/s41598-020-80089-4.
3
Prolonged cholestasis after acute viral hepatitis: successfully treated with oral steroid.急性病毒性肝炎后迁延性胆汁淤积：口服类固醇治疗成功。
BMJ Case Rep. 2020 May 21;13(5):e234430. doi: 10.1136/bcr-2020-234430.
4
Hepatitis A Outbreaks in Developed Countries: Detection, Control, and Prevention.甲型肝炎在发达国家的暴发：检测、控制和预防。
Foodborne Pathog Dis. 2020 Mar;17(3):166-171. doi: 10.1089/fpd.2019.2648. Epub 2019 Dec 12.
5
Clinical characteristics and outcomes of acute hepatitis a in Korea: a nationwide multicenter study.韩国甲型肝炎急性肝炎的临床特征和结局：一项全国多中心研究。
J Korean Med Sci. 2014 Feb;29(2):248-53. doi: 10.3346/jkms.2014.29.2.248. Epub 2014 Jan 28.
6
Prolonged cholestasis following hepatitis a virus infection: revisiting the role of steroids.甲型肝炎病毒感染后的长期胆汁淤积：重新审视类固醇的作用。
J Glob Infect Dis. 2012 Jul;4(3):185-6. doi: 10.4103/0974-777X.100588.
7
Cholestatic syndrome in viral hepatitis A.甲型病毒性肝炎中的胆汁淤积综合征
Folia Med (Plovdiv). 2012 Jan-Mar;54(1):30-5. doi: 10.2478/v10153-011-0075-9.
8
Clinical courses after administration of oral corticosteroids in patients with severely cholestatic acute hepatitis A; three cases.严重胆汁淤积型甲型急性肝炎患者口服皮质类固醇后的临床病程；三例报告
Korean J Hepatol. 2010 Sep;16(3):329-33. doi: 10.3350/kjhep.2010.16.3.329.
9
Atypical manifestations of hepatitis A infection: a prospective, multicenter study in Korea.甲型肝炎感染的非典型表现：韩国一项前瞻性、多中心研究。
J Med Virol. 2010 Aug;82(8):1318-26. doi: 10.1002/jmv.21822.
10
Hepatitis A: clinical manifestations and management.甲型肝炎：临床表现与管理。
Intervirology. 2010;53(1):15-9. doi: 10.1159/000252779. Epub 2010 Jan 5.
Zotero 插件