Gordon S C, Reddy K R, Schiff L, Schiff E R
Ann Intern Med. 1984 Nov;101(5):635-7. doi: 10.7326/0003-4819-101-5-635.
Viral hepatitis characterized by prolonged cholestasis has not been associated with a specific serologic marker. We report the cases of six patients presenting with a clinical syndrome typical of cholestatic hepatitis who were subsequently found to have acute hepatitis A. Usual features include pruritus, fever, diarrhea, and weight loss with serum bilirubin levels greater than 10 mg/dL, and a clinical course lasting at least 12 weeks. All patients recovered completely without sequelae. Knowledge of this unusual manifestation of hepatitis A may help avoid potentially invasive procedures involved in the evaluation of suspected obstructive jaundice and facilitate appropriate immunoprophylactic measures.
以长期胆汁淤积为特征的病毒性肝炎与特定的血清学标志物无关。我们报告了6例表现为胆汁淤积性肝炎典型临床综合征的患者，随后发现他们患有甲型急性肝炎。常见症状包括瘙痒、发热、腹泻和体重减轻，血清胆红素水平大于10mg/dL，病程至少持续12周。所有患者均完全康复，无后遗症。了解甲型肝炎的这种不寻常表现可能有助于避免在评估疑似梗阻性黄疸时进行潜在的侵入性检查，并有助于采取适当的免疫预防措施。
