Center for Systemic Inflammation Research (CSIR), School of Preclinical Medicine, Youjiang Medical University for Nationalities, Baise, Guangxi Province, China.
Department of Renal Diseases, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning Guangxi Province, China.
Mediators Inflamm. 2023 May 27;2023:9810733. doi: 10.1155/2023/9810733. eCollection 2023.
Ferroptosis resistance is vital for B cell development, especially in inflammatory diseases, yet the underlying mechanism is still unclear. In this study, based on the scRNA-seq technique and flow cytometry, we discovered a proportion of neutrophils exhibited upregulated expression of the IL-6 and correlated with the expression of IL-6 receptor and SLC7A11 from B cells in lupus kidney. Moreover, we identified that in lupus kidney, neutrophils could provide IL-6 to facilitate ferroptosis resistance in B cells via SLC7A11, and inhibition of SLC7A11 could significantly enhance ferroptosis in B cells and could decrease B cell proliferation. This study helps understand the crosstalk between neutrophils and B cells in the kidney in the development of lupus.
铁死亡抵抗对于 B 细胞的发育至关重要，尤其是在炎症性疾病中，但其中的潜在机制尚不清楚。在这项研究中，我们基于 scRNA-seq 技术和流式细胞术，发现了一部分中性粒细胞中 IL-6 的表达上调，并且与狼疮性肾炎中 B 细胞的 IL-6 受体和 SLC7A11 的表达相关。此外，我们发现狼疮性肾炎中，中性粒细胞可以通过 SLC7A11 向 B 细胞提供 IL-6，从而促进其铁死亡抵抗，并且抑制 SLC7A11 可以显著增强 B 细胞的铁死亡，并减少其增殖。这项研究有助于理解在狼疮发生过程中肾脏中中性粒细胞和 B 细胞之间的相互作用。
