Department of Dermatology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.
National Engineering Research Center of Personalized Diagnostic and Therapeutic Technology, Changsha, Hunan 410008, China.
Chin Med J (Engl). 2024 Aug 5;137(15):1777-1789. doi: 10.1097/CM9.0000000000003164. Epub 2024 Jul 8.
Regulated cell death (RCD) is a critical physiological process essential in maintaining skin homeostasis. Among the various forms of RCD, ferroptosis stands out due to its distinct features of iron accumulation, lipid peroxidation, and involvement of various inhibitory antioxidant systems. In recent years, an expanding body of research has solidly linked ferroptosis to the emergence of skin disorders. Therefore, understanding the mechanisms underlying ferroptosis in skin diseases is crucial for advancing therapy and prevention strategies. This review commences with a succinct elucidation of the mechanisms that underpin ferroptosis, embarks on a thorough exploration of ferroptosis's role across a spectrum of skin conditions, encompassing melanoma, psoriasis, systemic lupus erythematosus (SLE), vitiligo, and dermatological ailments precipitated by ultraviolet (UV) exposure, and scrutinizes the potential therapeutic benefits of pharmacological interventions aimed at modulating ferroptosis for the amelioration of skin diseases.
细胞程序性死亡（RCD）是维持皮肤内稳态的关键生理过程。在各种形式的 RCD 中，铁死亡因其铁积累、脂质过氧化以及各种抑制性抗氧化系统的参与而具有独特的特征。近年来，越来越多的研究将铁死亡与皮肤疾病的发生联系起来。因此，了解铁死亡在皮肤疾病中的机制对于推进治疗和预防策略至关重要。本综述首先简要阐述了铁死亡的机制，然后全面探讨了铁死亡在一系列皮肤疾病中的作用，包括黑色素瘤、银屑病、系统性红斑狼疮（SLE）、白癜风以及紫外线（UV）暴露引起的皮肤病，并研究了旨在调节铁死亡以改善皮肤疾病的药理学干预的潜在治疗益处。
