Wang Jian, Guleria Sanjay, Koffas Mattheos Ag, Yan Yajun
College of Engineering, University of Georgia, Athens, Georgia 30602, United States.
Division of Biochemistry, Sher-e-Kashmir University of Agricultural Sciences and Technology, Main Campus Chatha-180009, Jammu, India.
Curr Opin Biotechnol. 2016 Feb;37:97-104. doi: 10.1016/j.copbio.2015.11.003. Epub 2015 Dec 21.
Nutraceuticals are important natural bioactive compounds that confer health-promoting and medical benefits to humans. Globally growing demands for value-added nutraceuticals for prevention and treatment of human diseases have rendered nutraceuticals a multi-billion dollar market. However, supply limitations and extraction difficulties from natural sources such as plants, animals or fungi, restrict the large-scale use of nutraceuticals. Metabolic engineering via microbial production platforms has been advanced as an eco-friendly alternative approach for production of value-added nutraceuticals from simple carbon sources. Microbial platforms like the most widely used Escherichia coli and Saccharomyces cerevisiae have been engineered as versatile cell factories for production of diverse and complex value-added chemicals such as phytochemicals, prebiotics, polysaccaharides and poly amino acids. This review highlights the recent progresses in biological production of value-added nutraceuticals via metabolic engineering approaches.
营养保健品是重要的天然生物活性化合物，对人类具有促进健康和医疗益处。全球对用于预防和治疗人类疾病的增值营养保健品的需求不断增长，使营养保健品成为一个价值数十亿美元的市场。然而，从植物、动物或真菌等天然来源获取营养保健品存在供应限制和提取困难，这限制了营养保健品的大规模使用。通过微生物生产平台进行代谢工程已成为一种环保的替代方法，可从简单碳源生产增值营养保健品。像最广泛使用的大肠杆菌和酿酒酵母这样的微生物平台已被设计成通用的细胞工厂，用于生产各种复杂的增值化学品，如植物化学物质、益生元、多糖和聚氨基酸。本文综述重点介绍了通过代谢工程方法生物生产增值营养保健品的最新进展。
