Li Biao, Li Haoran, Huang Qun, Zheng Yanlin
Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.
Front Neurol. 2023 May 18;14:1190279. doi: 10.3389/fneur.2023.1190279. eCollection 2023.
Pioneering advancements in optical coherence tomography (OCT) have facilitated the discernment of peripapillary hyper-reflective ovoid mass-like structures (PHOMS), prevalent neuro-ophthalmological findings associated with an array of ophthalmic conditions, such as optic disc drusen (ODD), papilledema, myopic/tilted optic discs, non-arteritic anterior ischemic optic neuropathy (NA-AION), and optic neuritis. Despite an expanding corpus of research, numerous inquiries persist concerning their clinical significance, correlations with ocular afflictions, and prognostic implications. This comprehensive review endeavors to impart an in-depth comprehension of PHOMS, encompassing facets like conceptualization, detection, pathogenesis, and associations with diverse ophthalmic conditions. Furthermore, we underscore several unresolved quandaries and suggest prospective avenues for future exploration.
光学相干断层扫描（OCT）的开创性进展有助于识别视乳头周围高反射卵形肿块样结构（PHOMS），这是与一系列眼科疾病相关的常见神经眼科表现，如视盘小疣（ODD）、视乳头水肿、近视/倾斜视盘、非动脉性前部缺血性视神经病变（NA-AION）和视神经炎。尽管研究不断增加，但关于它们的临床意义、与眼部疾病的相关性以及预后影响仍有许多问题。本综述旨在深入理解PHOMS，包括其概念、检测、发病机制以及与各种眼科疾病的关联等方面。此外，我们强调了几个尚未解决的难题，并提出了未来探索的潜在途径。
