Department of Ophthalmology and Visual Science, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Eye (Lond). 2022 Mar;36(3):533-539. doi: 10.1038/s41433-021-01461-w. Epub 2021 Mar 17.
To analyse structural characteristics and perifoveal/peripapillary vasculature by OCT in children with peripapillary hyperreflective ovoid mass-like structures (PHOMS) and compare the results with those of normal subjects.
Forty-five patients (84 eyes) under 18 years old with blurry disc margin were evaluated with spectral domain-OCT and swept course-OCT. Patients were divided into four groups, according to presence of PHOMS and then the size of the existing PHOMS. Eyes with visible optic disc drusen (ODD) were not included. Foveal avascular zone (FAZ) and vessel densities from macula and optic disc area were assessed and potential associations between vessel density and structural parameters, such as peripapillary retinal nerve fibre layer (pRNFL), and macular ganglion cell and inner plexiform layer (mGCIPL) thickness, were analysed.
Among 45 patients (eighty-four eyes), coexisting buried ODD were found only in eyes with PHOMS. The scleral canal diameter was significantly smaller in PHOMS positive eyes compared to control eyes. Vessel density measurements from the papillary, peripapillary and optic nerve head (ONH) regions in the large PHOMS group were significantly lower compared to the control group (papillary; P = 0.014, peripapillary; P = 0.001, ONH; P = 0.046). FAZ area and macular vessel densities showed no difference compared to normal eyes in all three PHOMS groups. pRNFL and mGCIPL thickness did not differ among four groups and correlations were also not significant.
Children with PHOMS have smaller scleral canal and can entail buried ODD. Vessel densities of optic disc area in large PHOMS eyes are significantly lower than in normal eyes.
通过 OCT 分析患有神经纤维层下高反射卵圆形结构（PHOMS）的儿童的结构特征和视盘周围/神经纤维层下血管，将结果与正常受试者进行比较。
对 45 名（84 只眼）年龄在 18 岁以下的视盘边缘模糊患者进行了频域 OCT 和扫频 OCT 检查。根据是否存在 PHOMS 以及现有的 PHOMS 大小将患者分为四组。不包括可见视盘玻璃膜疣（ODD）的眼睛。评估了黄斑中心凹无血管区（FAZ）和来自黄斑及视盘区域的血管密度，并分析了血管密度与结构参数（如神经纤维层（pRNFL）、黄斑神经节细胞和内丛状层（mGCIPL）厚度）之间的潜在关联。
在 45 名患者（84 只眼）中，仅在存在 PHOMS 的眼中发现了共存的埋藏性 ODD。与对照组相比，PHOMS 阳性眼的巩膜管直径明显更小。与对照组相比，大 PHOMS 组的视盘、视盘周围和视神经头（ONH）区域的血管密度测量值显著降低（视盘；P = 0.014，视盘周围；P = 0.001，ONH；P = 0.046）。在所有三组 PHOMS 中，FAZ 面积和黄斑血管密度与正常眼相比无差异。四组之间的 pRNFL 和 mGCIPL 厚度无差异，相关性也不显著。
患有 PHOMS 的儿童的巩膜管较小，可能存在埋藏性 ODD。大 PHOMS 眼的视盘区域血管密度明显低于正常眼。
