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[Adsorbed subunit influenza vaccine: its isolation and characteristics].

作者信息

Shapiro N I, Zhukova T Ia, Shpiliuk G F, Entina N N, Konstantinov V K

出版信息

Virologie. 1986 Apr-Jun;37(2):125-9.

PMID:3727396
Abstract

Experimental batches of adsorbed subunit influenza vaccine were prepared from the envelope of glycoprotein antigens separated from the influenza virion by treatment with a cationic detergent (cetyltrimethylammonium bromide). Purified and concentrated influenza virus strains A(H1N1) and A(H3N2) were obtained by gradient centrifugation; additional purification, with a view to removing ovalbumin and structural components of the chorioallantoic membrane, was achieved by gelfiltration. The composition and biological properties of the vaccine are described.

摘要

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