Ryzhenkov V E, Pankov Iu A, Chistiakova A M, Keda Iu M, Serrano D S
Vopr Med Khim. 1986 May-Jun;32(3):108-11.
Although synthetic tetradecapeptide, involving the 31-44 amino acid sequence of human growth hormone, exhibited a distinct lipolytic effect, content of triglycerides was not increased in rat blood and liver tissue during chronic experiments. At the same time, the level of atherogenic lipoproteins as well as activities of postheparin lipase and liver triglyceride lipase were also unaltered. The data obtained suggest that the tetradecapeptide studied stimulated simultaneously both lipolysis and oxidation of free fatty acids.
尽管包含人生长激素31 - 44氨基酸序列的合成十四肽表现出明显的脂解作用，但在慢性实验期间，大鼠血液和肝脏组织中的甘油三酯含量并未增加。同时，致动脉粥样硬化脂蛋白水平以及肝素后脂肪酶和肝脏甘油三酯脂肪酶的活性也未改变。所获得的数据表明，所研究的十四肽同时刺激了脂解作用和游离脂肪酸的氧化。
