[Effect of synthetic tetradecapeptide corresponding to 31-44 amino acid sequence of growth hormone on lipolysis in human adipose tissue].

Fat mobilyzing activity of synthetic tetradecapeptide, which corresponds in 31--44 amino acid sequence of human growth hormone, is studied in vitro in human fat tissue. The peptide at concentrations of 3--33 microng/ml considerably stimulated lipolysis in subdermal fat tissue, omentum and shoulder ateroma. Minimal efficient peptide concentration was 3 microng/ml in most experiments, sometimes it was 0.3 microng/ml. Direct dependency between dose logarithm and lipolysis rate was observed at dose interval of 0.3--18 microng/ml. Native growth hormone produced no activity in human fat tissue even in concentrations of 50--100 microng/ml.