Lee Charlotte, Hahn Rebecca T
Department of Cardiology, Columbia University Medical Center/NY Presbyterian Hospital, New York, New York, USA.
Struct Heart. 2022 Oct 31;7(2):100104. doi: 10.1016/j.shj.2022.100104. eCollection 2023 Mar.
Valvular heart disease can develop as a long-term side effect of radiation therapy, along with other cardiovascular complications. The timeline until clinically significant disease can be on the order of decades, with left-sided valves most commonly affected. Only a few retrospective studies have characterized the incidence and findings associated with radiation therapy associated valvular heart disease. Furthermore, treatment can be difficult in this population given certain factors that can contribute to high surgical risk. In recent years, however, the development of transcatheter options for valvular disease has led to expanded eligibility criteria for cancer patients who may receive radiation therapy as part of their treatment course. We therefore sought to review the literature on radiation-induced valvular heart disease and provide an overview of recent studies on post-intervention outcomes in these patients.
心脏瓣膜病可能作为放射治疗的长期副作用而出现，同时伴有其他心血管并发症。直到出现具有临床意义的疾病的时间跨度可能长达数十年，其中左侧瓣膜最常受到影响。仅有少数回顾性研究对与放射治疗相关的心脏瓣膜病的发病率及相关发现进行了描述。此外，鉴于某些因素会导致手术风险增高，对这一人群的治疗可能会很困难。然而，近年来，用于瓣膜病的经导管治疗方案的发展使得癌症患者的入选标准得以扩大，这些患者可能在其治疗过程中接受放射治疗。因此，我们试图回顾有关放射性心脏瓣膜病的文献，并概述这些患者干预后结果的近期研究。
