基于风险评分的来特莫韦在脐带血移植中的应用。 - Suppr

Use of letermovir in umbilical cord blood transplantation based on risk scores.

作者信息

Rivera Franco Monica M, Rafii Hanadi, Volt Fernanda, Kenzey Chantal, Cappelli Barbara, Scigliuolo Graziana Maria, Rocha Vanderson, Raus Nicole, Dalle Jean-Hugues, Chevallier Patrice, Robin Marie, Rubio Marie Thérèse, Ruggeri Annalisa, Gluckman Eliane

机构信息

Eurocord, Hôpital Saint Louis APHP, Institut de Recherche de Saint-Louis (IRSL) EA3518, Université de Paris Cité, Paris, France.

Monacord, Centre Scientifique de Monaco, Monaco, Monaco.

出版信息

Blood Adv. 2023 Aug 22;7(16):4315-4318. doi: 10.1182/bloodadvances.2023010573.

DOI:10.1182/bloodadvances.2023010573

PMID:37276384

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10424128/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f24/10424128/6162135d30f6/BLOODA_ADV-2023-010573-gr1.jpg

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Use of letermovir in umbilical cord blood transplantation based on risk scores.基于风险评分的来特莫韦在脐带血移植中的应用。

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Delayed-onset cytomegalovirus infection is frequent after discontinuing letermovir in cord blood transplant recipients.停药后迟发性巨细胞病毒感染在脐血移植受者中很常见。

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Use of Letermovir for Salvage Therapy for Resistant Cytomegalovirus in a Pediatric Hematopoietic Stem Cell Transplant Recipient.来特莫韦用于儿童造血干细胞移植受者耐巨细胞病毒挽救治疗的研究

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Letermovir Discontinuation at Day 100 After Allogeneic Stem Cell Transplant Is Associated With Increased CMV-Related Mortality.异基因干细胞移植后第 100 天停用洛韦特停药与 CMV 相关死亡率增加相关。

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[Umbilical cord hematopoietic precursors transplantation. Report of five patients].[脐带造血前体细胞移植。5例患者的报告]

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[New techniques for umbilical cord blood transplantation].[脐带血移植的新技术]

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Diffuse alveolar hemorrhage is most often fatal and is affected by graft source, conditioning regimen toxicity, and engraftment kinetics.弥漫性肺泡出血大多是致命的，受移植物来源、预处理方案毒性和植入动力学的影响。

Haematologica. 2018 Dec;103(12):2109-2115. doi: 10.3324/haematol.2018.189134. Epub 2018 Aug 3.

Hematopoietic stem cell transplantation using umbilical cord blood progenitors: review of current clinical results.使用脐带血祖细胞进行造血干细胞移植：当前临床结果综述

Bone Marrow Transplant. 2004 Apr;33(7):675-90. doi: 10.1038/sj.bmt.1704405.

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Cytomegalovirus breakthrough and resistance during letermovir prophylaxis.来特莫韦预防期间的巨细胞病毒突破和耐药性。

Bone Marrow Transplant. 2023 Apr;58(4):430-436. doi: 10.1038/s41409-023-01920-w. Epub 2023 Jan 24.

The promising efficacy of a risk-based letermovir use strategy in CMV-positive allogeneic hematopoietic cell recipients.基于风险的更昔洛韦使用策略在 CMV 阳性异基因造血细胞受者中的良好疗效。

Blood Adv. 2023 Mar 14;7(5):856-865. doi: 10.1182/bloodadvances.2022008667.

Extended-duration letermovir prophylaxis for cytomegalovirus infection after cord blood transplantation in adults.成人脐带血移植后延长疗程更昔洛韦预防巨细胞病毒感染。

Blood Adv. 2022 Dec 27;6(24):6291-6300. doi: 10.1182/bloodadvances.2022008047.

Risk of Cytomegalovirus Infection with Post-Transplantation Cyclophosphamide in Haploidentical and HLA-Matched Unrelated Donor Transplantation.移植后环磷酰胺在单倍体相合和 HLA 匹配的无关供者移植中巨细胞病毒感染的风险。

Transplant Cell Ther. 2022 Apr;28(4):213.e1-213.e6. doi: 10.1016/j.jtct.2022.01.011. Epub 2022 Jan 21.

A CMV seronegative donor to avoid T-cell inflation?

Blood. 2021 Dec 30;138(26):2751-2752. doi: 10.1182/blood.2021012723.

American Society for Transplantation and Cellular Therapy Series: #4 - Cytomegalovirus treatment and management of resistant or refractory infections after hematopoietic cell transplantation.美国移植与细胞治疗学会系列：#4 - 造血细胞移植后巨细胞病毒治疗和耐药或难治性感染的管理。

Transplant Cell Ther. 2021 Dec;27(12):957-967. doi: 10.1016/j.jtct.2021.09.010. Epub 2021 Sep 21.

Delayed-onset cytomegalovirus infection is frequent after discontinuing letermovir in cord blood transplant recipients.停药后迟发性巨细胞病毒感染在脐血移植受者中很常见。

Blood Adv. 2021 Aug 24;5(16):3113-3119. doi: 10.1182/bloodadvances.2021004362.

Scoring system for clinically significant CMV infection in seropositive recipients following allogenic hematopoietic cell transplant: an SFGM-TC study.CMV 感染的临床意义评分系统在异基因造血细胞移植后血清阳性受者中的应用：一项 SFGM-TC 研究。

Bone Marrow Transplant. 2021 Jun;56(6):1305-1315. doi: 10.1038/s41409-020-01178-6. Epub 2020 Dec 18.

Letermovir Prophylaxis for Cytomegalovirus in Hematopoietic-Cell Transplantation.来特莫韦预防造血干细胞移植后巨细胞病毒感染。

N Engl J Med. 2017 Dec 21;377(25):2433-2444. doi: 10.1056/NEJMoa1706640. Epub 2017 Dec 6.

Regression coefficient-based scoring system should be used to assign weights to the risk index.基于回归系数的评分系统应被用于为风险指数赋权。

J Clin Epidemiol. 2016 Nov;79:22-28. doi: 10.1016/j.jclinepi.2016.03.031. Epub 2016 May 13.

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Use of letermovir in umbilical cord blood transplantation based on risk scores.

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