在中国成年人冠心病患者中，载脂蛋白 A1 和高密度脂蛋白胆固醇与血红蛋白糖化指数和甘油三酯-葡萄糖指数的相关性。

Associations of apolipoproteinA1, high density lipoprotein cholesterol with hemoglobin glycation index and triglyceride-glucose index in Chinese adults with coronary artery disease.

机构信息

Department of Child Healthcare and Scientific Education Section, Affiliated Maternity & Child Health Care Hospital of Nantong University, Nantong, Jiangsu, China.

Image Center, Wuhan Asia Heart Hospital, Wuhan, Hubei, China.

出版信息

J Diabetes Complications. 2023 Aug;37(8):108516. doi: 10.1016/j.jdiacomp.2023.108516. Epub 2023 May 30.

DOI:10.1016/j.jdiacomp.2023.108516

PMID:37276657

Abstract

AIMS

Scarce data explored the associations of apolipoproteins with hemoglobin glycation index (HGI) and triglyceride-glucose (TyG) index. This study determined associations of serum apolipoproteinA1 (ApoA1) and high density lipoprotein cholesterol (HDL-C) with HGI and TyG index in coronary artery disease (CAD) patients.

METHODS

A total of 10,803 CAD patients were included in this cross-sectional pilot study. Serum concentrations of ApoA1 and HDL-C were measured. Analyses of covariance were used to compare the mean differences in glucose metabolism indices (e.g., HGI, TyG index, hemoglobin glycation [HbA1c], fasting blood glucose [FBG]) among the quartiles of ApoA1, HDL-C and HDL-C/ApoA1 ratio.

RESULTS

In multivariate analysis, higher ApoA1, HDL-C and HDL-C/ApoA1 ratio were associated with significantly lower HGI (Quartile [Q]4 vs. Q1: -0.032 % vs. 0.017 % for ApoA1; -0.072 % vs. 0.079 % for HDL-C; -0.083 % vs. 0.085 % for HDL-C/ApoA1 ratio). Intermediate ApoA1 level was inversely associated with TyG index (Q2 vs. Q1: 296.278 vs. 306.794). The mean TyG index were significantly decreased with increased HDL-C and HDL-C/ApoA1 ratio (Q4 vs. Q1: 298.584 vs. 309.221 for HDL-C; 300.405 vs. 315.218 for HDL-C/ApoA1 ratio). Moreover, the inverse associations of ApoA1, HDL-C and HDL-C/ApoA1 ratio with HbA1c and FBG also were observed. In path analysis, the associations of HDL-C and HDL-C/ApoA1 ratio with TyG index were mediated by obesity.

CONCLUSION

This study provided further support for the hypoglycemic effects of ApoA1 and HDL-C in patients with CAD. Replication of these findings is warranted in further longitudinal studies in different populations.

摘要

目的

载脂蛋白与血红蛋白糖化指数（HGI）和甘油三酯-葡萄糖（TyG）指数的关联研究数据较为匮乏。本研究旨在探讨冠心病（CAD）患者血清载脂蛋白 A1（ApoA1）和高密度脂蛋白胆固醇（HDL-C）与 HGI 和 TyG 指数的相关性。

方法

本横断面研究纳入了 10803 例 CAD 患者。检测血清 ApoA1 和 HDL-C 浓度。采用协方差分析比较 ApoA1、HDL-C 和 HDL-C/ApoA1 比值四分位数的葡萄糖代谢指标（如 HGI、TyG 指数、糖化血红蛋白 [HbA1c]、空腹血糖 [FBG]）的均值差异。

结果

在多变量分析中，较高的 ApoA1、HDL-C 和 HDL-C/ApoA1 比值与 HGI 显著降低相关（四分位数[Q]4 与 Q1 相比：ApoA1 为-0.032%与 0.017%；HDL-C 为-0.072%与 0.079%；HDL-C/ApoA1 比值为-0.083%与 0.085%）。ApoA1 水平处于中间值时与 TyG 指数呈负相关（Q2 与 Q1 相比：296.278 与 306.794）。随着 HDL-C 和 HDL-C/ApoA1 比值的增加，TyG 指数的均值显著降低（Q4 与 Q1 相比：HDL-C 为 298.584 与 309.221；HDL-C/ApoA1 比值为 300.405 与 315.218）。此外，还观察到 ApoA1、HDL-C 和 HDL-C/ApoA1 比值与 HbA1c 和 FBG 呈负相关。路径分析显示，HDL-C 和 HDL-C/ApoA1 比值与 TyG 指数的相关性可通过肥胖程度来介导。