School of Biological Engineering, Henan University of Technology, Zhengzhou, 450001, Henan, People's Republic of China.
School of Biological Engineering, Henan University of Technology, Zhengzhou, 450001, Henan, People's Republic of China.
Toxicon. 2023 Aug 1;231:107177. doi: 10.1016/j.toxicon.2023.107177. Epub 2023 Jun 3.
Aflatoxin B1 (AFB1) is widely distributed in crops and feeds, and ingestion of AFB1-contaminated crops is harmful to human/animal health. This study was designed to investigate hepatoprotective effects of chlorogenic acid (CGA), due to its excellent antioxidant and anti-inflammatory activities, on mice exposed to AFB1. Male Kunming mice were orally fed with CGA prior to daily AFB1 exposure for 18 consecutive days. The results showed that CGA treatment reduced the serum activity of aspartate aminotransferase, hepatic malondialdehyde content and pro-inflammatory cytokines synthesis, prevented histopathological changes of the liver, increased hepatic glutathione level, catalase activity and IL10 mRNA expression in mice subjected to AFB1. Taken together, CGA exerted the protective effect on AFB1-induced hepatic damage by modulating redox status and inflammation, suggesting that CGA may be a candidate compound for the treatment of aflatoxicosis.
黄曲霉毒素 B1（AFB1）广泛存在于农作物和饲料中，摄入被 AFB1 污染的农作物会对人类/动物健康造成危害。本研究旨在探讨绿原酸（CGA）由于其出色的抗氧化和抗炎活性，对接触 AFB1 的小鼠的肝脏保护作用。雄性昆明小鼠在每日接触 AFB1 前连续 18 天口服 CGA。结果表明，CGA 处理可降低血清天冬氨酸氨基转移酶活性、肝丙二醛含量和促炎细胞因子的合成，防止 AFB1 引起的小鼠肝脏组织病理学变化，增加肝内谷胱甘肽水平、过氧化氢酶活性和 IL10mRNA 表达。综上所述，CGA 通过调节氧化还原状态和炎症发挥对 AFB1 诱导的肝损伤的保护作用，表明 CGA 可能是治疗黄曲霉毒素中毒的候选化合物。
