Cheng Kang, Yao Jinxiu, Song Zhihua, Huang Jin, Zhao Hongyue, Yang Ranya, Meng Yao, Wang Jinrong, Zhang Yong
Guangzhou Tanke Bio-Tech Co., Ltd., Guangzhou 510896, China.
School of Biological Engineering, Henan University of Technology, Zhengzhou 450001, China.
Animals (Basel). 2025 Jan 21;15(3):290. doi: 10.3390/ani15030290.
This study investigated the effects of resveratrol (RSV) on redox status, jejunal injury, and mitochondrial function in intrauterine growth-retarded (IUGR) weaned piglets. In total, 12 male normal birth weight (NBW) newborn piglets and 24 male IUGR newborn piglets were selected. They were weaned at 26 days of age and then divided into three treatments in a three-week trial: (1) NBW piglets fed a basal diet; (2) IUGR piglets fed a basal diet; (3) IUGR piglets fed a basal diet supplemented with 300 mg/kg RSV. Compared with NBW piglets, IUGR piglets showed decreased growth performance, altered redox status, impaired jejunal morphology, tight junction protein expression, energy production, and mitochondrial oxidative phosphorylation. RSV enhanced antioxidant defense capacity and improved jejunal morphology, ATP generation, and mitochondrial complex I content in IUGR weaned piglets. Dietary RSV supplementation alleviated the IUGR-induced jejunal injury in weaned piglets probably by improving redox status and mitochondrial function, suggesting that RSV has the potential to be a dietary intervention in the regulation of intestinal injury in IUGR piglets.
本研究调查了白藜芦醇（RSV）对宫内生长受限（IUGR）断奶仔猪氧化还原状态、空肠损伤和线粒体功能的影响。总共挑选了12头雄性正常出生体重（NBW）新生仔猪和24头雄性IUGR新生仔猪。它们在26日龄时断奶，然后在为期三周的试验中分为三种处理：（1）NBW仔猪饲喂基础日粮；（2）IUGR仔猪饲喂基础日粮；（3）IUGR仔猪饲喂添加300 mg/kg RSV的基础日粮。与NBW仔猪相比，IUGR仔猪生长性能下降，氧化还原状态改变，空肠形态受损，紧密连接蛋白表达、能量产生和线粒体氧化磷酸化受到损害。RSV增强了IUGR断奶仔猪的抗氧化防御能力，改善了空肠形态、ATP生成和线粒体复合体I含量。日粮中添加RSV可能通过改善氧化还原状态和线粒体功能减轻了IUGR断奶仔猪空肠损伤，表明RSV有潜力作为一种饮食干预措施来调节IUGR仔猪的肠道损伤。
