Qiu Lingyan, Chen Kai, Wang Xu, Zhao Yun
Nanjing University of Chinese Medicine, 66478, 138 Xianlin Avenue, Qixia District, Nanjing, Jiangsu, China, Nanjing, China, 210046;
Nanjing University of Traditional Chinese Medicine, 66478, Nanjing, Jiangsu, China;
Rejuvenation Res. 2023 Jun 6. doi: 10.1089/rej.2023.0013.
The publisher of Rejuvenation Research officially retracts the article entitled, "Tangzhiqing-mediated NRF2 reduces autophagy-dependent ferroptosis to mitigate diabetes-related cognitive impairment neuronal damage," by Lingyan Qiu, Mr. Kai Chen, Prof. Xu Wang, and Ms. Yun Zhao. (Rejuvenation Res 2023; epub 6 Jun; doi: 10.1089/rej.2023.0013). After the acceptance and Instant Online publication of the paper, the authors were contacted repeatedly regarding their page proofs, and for further clarification of unresolved issues within the paper. All attempts to reach the authors were unsuccessful. Concurrently, the publisher identified a problematic overlap with a paper published in 2023 in Endocrine, Metabolic & Immune Disorders - Drug Targets. This paper was subsequently withdrawn. These troubling details have led the editorial leadership of Rejuvenation Research to lose confidence in the validity of the submission and to retract the paper. All authors were notified of the decision to retract the paper via email. The lead author, Lingyan Qiu, and the corresponding author, Xu Wang, quickly responded and appealed the decision to retract. The appeal was denied. Reference 1. https://www.eurekaselect.com/article/132631. Withdrawn: Experimental study on NRF2 mediated by Chinese medicine tangzhiqing to reduce autophagy-dependent ferroptosis and alleviate neuron damage in HT22 mice with diabetes-related cognitive disorder. 22 June, 2023; DOI: 10.2174/1871530323666230622151649 Diabetes is a chronic condition defined by the body's inability to process glucose. The most common form, diabetes mellitus, reflects the body's insulin resistance, which leads to long-term raised glucose blood levels. These levels can cause oxidative damage, cell stress, and excessive autophagy throughout the body, including the nervous system. Diabetes-related cognitive impairment (DCI) results from chronic elevation of blood glucose, and as diabetes cases continue to rise, so too do comorbidities such as DCI. Although there are medications to address high blood glucose, there are few that can inhibit excessive autophagy and cell death. Therefore, we investigated if the Traditional Chinese Medicine, Tangzhiqing (TZQ), can reduce the impact of DCI in a high-glucose cell model. We used commercially available kits to evaluate cell viability, mitochondrial activity, and oxidative stress. We found that TZQ treatment increased cell viability, ensured continued mitochondrial activity, and reduced reactive oxygen species. We also found that TZQ functions by increasing NRF2 activity, which decreases the ferroptotic-associated pathways that involve p62, HO-1, and GPX4. Therefore, TZQ should be further investigated for its role in reducing DCI.
《返老还童研究》的出版商正式撤回了由邱灵燕、陈凯先生、王许教授和赵芸女士撰写的题为“糖脂清介导的NRF2减少自噬依赖性铁死亡以减轻糖尿病相关认知障碍神经元损伤”的文章。（《返老还童研究》2023年；电子版于6月6日发布；doi:10.1089/rej.2023.0013）。在该论文被接受并即时在线发表后，就其校样多次联系作者，以进一步澄清论文中未解决的问题。所有联系作者的尝试均未成功。同时，出版商发现该论文与2023年发表在《内分泌、代谢与免疫疾病 - 药物靶点》上的一篇论文存在有问题的重叠。该论文随后被撤回。这些令人不安的细节导致《返老还童研究》的编辑领导层对该投稿的有效性失去信心，并撤回该论文。已通过电子邮件将撤回论文的决定通知了所有作者。第一作者邱灵燕和通讯作者王许迅速做出回应并对撤回决定提出上诉。上诉被驳回。参考文献1.https://www.eurekaselect.com/article/132631。撤回：中药糖脂清介导NRF2减少自噬依赖性铁死亡并减轻糖尿病相关认知障碍HT22小鼠神经元损伤的实验研究。2023年6月22日；DOI:10.2174/1871530323666230622151649糖尿病是一种慢性病，其定义为身体无法处理葡萄糖。最常见的形式是糖尿病，反映了身体的胰岛素抵抗，这会导致血糖长期升高。这些水平会导致全身包括神经系统的氧化损伤、细胞应激和过度自噬。糖尿病相关认知障碍（DCI）由血糖长期升高引起，随着糖尿病病例的持续增加，DCI等合并症也在增加。尽管有药物可用于控制高血糖，但很少有药物能够抑制过度自噬和细胞死亡。因此，我们研究了中药糖脂清（TZQ）是否能在高糖细胞模型中减轻DCI的影响。我们使用市售试剂盒评估细胞活力、线粒体活性和氧化应激。我们发现TZQ处理可提高细胞活力，确保线粒体持续活动，并减少活性氧。我们还发现TZQ通过增加NRF2活性发挥作用，这会减少涉及p62、HO-1和GPX4的铁死亡相关途径。因此，应进一步研究TZQ在减轻DCI方面的作用。
