2022 年 SARS-CoV-2 血清免疫与儿童青少年感染和疫苗接种相关的生活质量：IMMUNEBRIDGE KIDS 横断面研究。
SARS-CoV-2 sero-immunity and quality of life in children and adolescents in relation to infections and vaccinations: the IMMUNEBRIDGE KIDS cross-sectional study, 2022.
机构信息
Department of Pediatrics, University Hospital Würzburg, Josef-Schneider-Straße 2, 97080, Würzburg, Germany.
Division of Epidemiology, Institute of Social Pediatrics and Adolescent Medicine, LMU Munich, Haydnstraße 5, 80336, Munich, Germany.
出版信息
Infection. 2023 Oct;51(5):1531-1539. doi: 10.1007/s15010-023-02052-5. Epub 2023 Jun 6.
PURPOSE
The study evaluates the effects on sero-immunity, health status and quality of life of children and adolescents after the upsurge of the Omicron variant in Germany.
METHODS
This multicenter cross-sectional study (IMMUNEBRIDGE Kids) was conducted within the German Network University Medicine (NUM) from July to October 2022. SARS-CoV-2- antibodies were measured and data on SARS-CoV-2 infections, vaccinations, health and socioeconomic factors as well as caregiver-reported evaluation on their children's health and psychological status were assessed.
RESULTS
497 children aged 2-17 years were included. Three groups were analyzed: 183 pre-schoolchildren aged 2-4 years, 176 schoolchildren aged 5-11 years and 138 adolescents aged 12-18 years. Positive antibodies against the S- or N-antigen of SARS-CoV-2 were detected in 86.5% of all participants (70.0% [128/183] of pre-schoolchildren, 94.3% of schoolchildren [166/176] and 98.6% of adolescents [136/138]). Among all children, 40.4% (201/497) were vaccinated against COVID-19 (pre-schoolchildren 4.4% [8/183], schoolchildren 44.3% [78/176] and adolescents 83.3% [115/138]). SARS-CoV-2 seroprevalence was lowest in pre-school. Health status and quality of life reported by the parents were very positive at the time of the survey (Summer 2022).
CONCLUSION
Age-related differences on SARS-CoV-2 sero-immunity could mainly be explained by differences in vaccination rates based on the official German vaccination recommendations as well as differences in SARS-CoV-2 infection rates in the different age groups. Health status and quality of life of almost all children were very good independent of SARS-CoV-2 infection and/or vaccination.
TRIAL REGISTRATION
German Registry for Clinical Trials Identifier Würzburg: DRKS00025546 (registration: 11.09.2021), Bochum: DRKS00022434 (registration:07.08.2020), Dresden: DRKS 00022455 (registration: 23.07.2020).
目的
本研究评估了德国奥密克戎变异株爆发后儿童和青少年的血清免疫、健康状况和生活质量的影响。
方法
本研究是一项多中心的横断面研究（IMMUNEBRIDGE Kids），于 2022 年 7 月至 10 月在德国大学医学网络（NUM）内进行。检测了 SARS-CoV-2 抗体，并评估了 SARS-CoV-2 感染、疫苗接种、健康和社会经济因素以及护理人员对其子女健康和心理状况的评估。
结果
共纳入 497 名 2-17 岁的儿童。分析了三组人群：2-4 岁的学龄前儿童 183 名，5-11 岁的学龄儿童 176 名，12-18 岁的青少年 138 名。所有参与者的 S-或 N-抗原 SARS-CoV-2 抗体阳性率为 86.5%（学龄前儿童为 70.0%[128/183]，学龄儿童为 94.3%[166/176]，青少年为 98.6%[136/138]）。所有儿童中，40.4%（201/497）接种了 COVID-19 疫苗（学龄前儿童 4.4%[8/183]，学龄儿童 44.3%[78/176]，青少年 83.3%[115/138]）。学龄前儿童的 SARS-CoV-2 血清阳性率最低。在调查时，父母报告的健康状况和生活质量非常积极（2022 年夏季）。
结论
年龄相关的 SARS-CoV-2 血清免疫差异主要可以通过基于德国官方疫苗接种建议的疫苗接种率差异以及不同年龄组 SARS-CoV-2 感染率差异来解释。几乎所有儿童的健康状况和生活质量都非常好，与 SARS-CoV-2 感染和/或疫苗接种无关。
研究注册
德国临床试验注册中心标识符 Würzburg：DRKS00025546（注册日期：2021 年 9 月 11 日），Bochum：DRKS00022434（注册日期：2020 年 8 月 7 日），Dresden：DRKS 00022455（注册日期：2020 年 7 月 23 日）。
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