Höppner Jakob, Maier Christoph, Schlegtendal Anne, Hoffmann Anna, Petersmann Astrid, Lücke Thomas, Toepfner Nicole, Brinkmann Folke
University Children's Hospital, St. Josef-Hospital, Ruhr-University Bochum, Bochum, Germany.
Institute for Clinical Chemistry and Laboratory Medicine, University Medicine Oldenburg, Oldenburg, Germany.
Sci Rep. 2025 Jan 23;15(1):2921. doi: 10.1038/s41598-024-84140-6.
During the omicron wave of the COVID-19 pandemic and with SARS-CoV-2 vaccines becoming available, seroprevalence rates rose in children and adolescents. This study investigated the impact of both SARS-CoV-2 infections and vaccinations on the incidence of acute and prolonged symptoms in real-world conditions during the transition from the pandemic to the endemic phase. Participants from a pediatric population based seroprevalence study (CorKID study) were followed up at least two and for almost four years by survey of health status features and symptoms suggestive of post-COVID syndrome (PCS). In a subgroup (n = 259) SARS-CoV-2 antibody serology was further investigated. 789 participants of the original CorKID study cohort (n = 2.121; 37.2%) were included. 67.9% reported at least one SARS-CoV2 infection. 46.6% had received one or more SARS-CoV-2 vaccinations. In the vast majority of serologically tested participants antibodies again SARS-CoV-2 spike (98.9%) or nucleocapsid (93.3%) antigen were detected following infection and/or vaccination. At least 30% experienced one unrecognized SARS-CoV-2 infection. The overall health status was comparable between children, irrespective of SARS-CoV-2 infections and similar to pre-pandemic assessment. However, a subset of young adolescents exhibited a decline in physical performance compared to pre-pandemic conditions. After infection, PCS-like symptoms persisted in 7% of the respondents for more than three months and up to four years. SARS-CoV-2 vaccinated participants (47%) reported 12% less acute flu-like infections other than SARS-CoV-2. Nearly all participants developed SARS-CoV-2 antibodies in this longitudinal study through either vaccination or infection during the Omicron wave. About 7% of participants suffered from PCS symptoms, predominately fatigue and exhaustion. Furthermore, participants who received vaccinations against SARS-CoV-2 reported a lower frequency of acute infections during follow-up.
在新冠疫情的奥密克戎浪潮期间，随着新冠病毒疫苗的普及，儿童和青少年的血清流行率有所上升。本研究调查了在从疫情流行阶段过渡到地方流行阶段的实际情况下，新冠病毒感染和疫苗接种对急性和长期症状发生率的影响。通过对健康状况特征和提示新冠后综合征（PCS）的症状进行调查，对来自一项基于儿科人群的血清流行率研究（CorKID研究）的参与者进行了至少两年、近四年的随访。在一个亚组（n = 259）中，对新冠病毒抗体血清学进行了进一步研究。原始CorKID研究队列中的789名参与者（n = 2121；37.2%）被纳入研究。67.9%的参与者报告至少感染过一次新冠病毒。46.6%的参与者接种过一剂或多剂新冠病毒疫苗。在绝大多数接受血清学检测的参与者中，感染和/或接种疫苗后检测到针对新冠病毒刺突蛋白（98.9%）或核衣壳蛋白（93.3%）抗原的抗体。至少30%的参与者经历过一次未被识别的新冠病毒感染。无论是否感染新冠病毒，儿童的总体健康状况相当，且与疫情前评估相似。然而，与疫情前相比，一部分青少年的身体机能有所下降。感染后，7%的受访者出现了持续三个月以上、长达四年的类似PCS的症状。接种新冠病毒疫苗的参与者（47%）报告除新冠病毒外的急性流感样感染减少了12%。在这项纵向研究中，几乎所有参与者通过在奥密克戎浪潮期间接种疫苗或感染都产生了新冠病毒抗体。约7%的参与者出现了PCS症状，主要是疲劳和疲惫。此外，接种新冠病毒疫苗的参与者在随访期间报告的急性感染频率较低。
