Department of Pharmaceutics, School of Pharmaceutical Sciences, Capital Medical University, Beijing, China.
Beijing Area Major Laboratory of Peptide and Small Molecular Drugs, Beijing, China.
Endocrinol Metab (Seoul). 2023 Jun;38(3):315-327. doi: 10.3803/EnM.2023.1621. Epub 2023 Jun 7.
To date, consistent data have not been reported on the association between serum amyloid A (SAA) levels and type 2 diabetes mellitus (T2DM). The purpose of this study was to systematically summarize their relationship.
Databases including PubMed, Cochrane Library, Embase, Web of Science, and MEDLINE were searched until August 2021. Cross-sectional and case-control studies were included.
Twenty-one studies with 1,780 cases and 2,070 controls were identified. SAA levels were significantly higher in T2DM patients than in healthy groups (standardized mean difference [SMD], 0.68; 95% confidence interval [CI], 0.39 to 0.98). A subgroup analysis showed that the mean age of participants and the continent that participants were from were related to differences in SAA levels between cases and controls. Furthermore, in T2DM patients, SAA levels were positively associated with body mass index (r=0.34; 95% CI, 0.03 to 0.66), triglycerides (r=0.12; 95% CI, 0.01 to 0.24), fasting plasma glucose (r=0.26; 95% CI, 0.07 to 0.45), hemoglobin A1c (r=0.24; 95% CI, 0.16 to 0.33), homeostasis model assessment for insulin resistance (r=0.22; 95% CI, 0.10 to 0.34), C-reactive protein (r=0.77; 95% CI, 0.62 to 0.91), and interleukin-6 (r=0.42; 95% CI, 0.31 to 0.54), but negatively linked with highdensity lipoprotein cholesterol (r=-0.23; 95% CI, -0.44 to -0.03).
The meta-analysis suggests that high SAA levels may be associated with the presence of T2DM, as well as lipid metabolism homeostasis and the inflammatory response.
目前，尚未有关于血清淀粉样蛋白 A（SAA）水平与 2 型糖尿病（T2DM）之间关联的一致性数据。本研究旨在系统地总结它们之间的关系。
检索了 PubMed、Cochrane 图书馆、Embase、Web of Science 和 MEDLINE 数据库，检索时间截至 2021 年 8 月。纳入了横断面和病例对照研究。
共纳入 21 项研究，包括 1780 例病例和 2070 例对照。T2DM 患者的 SAA 水平明显高于健康组（标准化均数差 [SMD]，0.68；95%置信区间 [CI]，0.39 至 0.98）。亚组分析表明，参与者的平均年龄和所在大陆与病例和对照组之间的 SAA 水平差异有关。此外，在 T2DM 患者中，SAA 水平与体重指数（r=0.34；95%CI，0.03 至 0.66）、三酰甘油（r=0.12；95%CI，0.01 至 0.24）、空腹血糖（r=0.26；95%CI，0.07 至 0.45）、糖化血红蛋白（r=0.24；95%CI，0.16 至 0.33）、胰岛素抵抗的稳态模型评估（r=0.22；95%CI，0.10 至 0.34）、C 反应蛋白（r=0.77；95%CI，0.62 至 0.91）和白细胞介素-6（r=0.42；95%CI，0.31 至 0.54）呈正相关，与高密度脂蛋白胆固醇（r=-0.23；95%CI，-0.44 至 -0.03）呈负相关。
荟萃分析表明，高水平的 SAA 可能与 T2DM 的发生以及脂质代谢平衡和炎症反应有关。
