Tanaka J, Takita T, Murase T, Shimoji T, Miyake K, Mitsuya H
Hinyokika Kiyo. 1986 Feb;32(2):241-8.
A 37-year-old man was sent to our department from the Radiology Department on July 19, 1984 with the diagnosis of right renal cell carcinoma with metastases to the right humerus and bilateral lungs. He was nephrectomized immediately and administered 10 X 10(6) units of alpha-interferon i. m. every other day for 3 months during the admission and 30 X 10(6) units once a week for more than 3 months after discharge. Although in addition to humeral and lung metastases, brain metastasis was found a week after the operation, interferon showed a remarkable effect and produced get a complete response in the humeral and brain metastases, and partial response in the lung metastasis. We think this is, perhaps, the first case of CR in brain metastasis so far. We conclude that interferon can be the first choice drug as an adjuvant chemotherapy against renal cell carcinoma.
1984年7月19日，一名37岁男性从放射科转至我科，诊断为右肾细胞癌伴右肱骨及双肺转移。入院期间，他立即接受了肾切除术，并每隔一天肌肉注射10×10⁶单位的α干扰素，共3个月；出院后，每周注射30×10⁶单位，持续3个多月。尽管术后一周发现除肱骨和肺转移外，还有脑转移，但干扰素显示出显著效果，肱骨和脑转移灶完全缓解，肺转移灶部分缓解。我们认为这可能是迄今为止脑转移出现完全缓解的首例病例。我们得出结论，干扰素可作为肾细胞癌辅助化疗的首选药物。
