Dorian P, Fain E S, Davy J M, Winkle R A
Am Heart J. 1986 Jul;112(1):19-25. doi: 10.1016/0002-8703(86)90672-1.
We examined the effect of bretylium and quinidine on the energy requirements for internal defibrillation in 14 pentobarbital-anesthetized dogs. Bretylium, 6 or 10 mg/kg (n = 6), did not affect the relation between energy and the likelihood of successful defibrillation. The mean energy required to achieve 50% success (E50) or 90% success (E90) in defibrillation was not significantly altered; E50 was 5.3 +/- 1.9 J (X +/- s.d) before and 6.1 +/- 3.5 J after bretylium (n.s.), and E90 was 7.2 +/- 2.1 J before and 8.6 +/- 3.3 J after drug (n.s.). Quinidine was administered in a series of two loading and maintenance infusions to achieve mean plasma concentrations of 2.4 +/- 0.63 and 2.95 +/- 0.88 microgram/ml, respectively (n = 8). No significant effect on defibrillation energy requirement was observed; mean E50 before and after treatment was 6.3 +/- 3.3 J and 6.2 +/- 2.9 J, respectively, and mean E90 was 8.3 +/- 4.4 J and 8.3 +/- 4.1 J, respectively. Similarly, saline administration to control dogs (n = 12) resulted in no change in E50 or E90. At concentrations or doses similar to those in patients with serious arrhythmias, neither quinidine nor bretylium appears to have consistent effects on the energy requirements for internal defibrillation in our dog model.
我们研究了溴苄铵和奎尼丁对14只戊巴比妥麻醉犬体内除颤能量需求的影响。给予6或10mg/kg溴苄铵（n = 6），未影响能量与成功除颤可能性之间的关系。除颤达到50%成功（E50）或90%成功（E90）所需的平均能量无显著改变；溴苄铵给药前E50为5.3±1.9J（X±标准差），给药后为6.1±3.5J（无统计学意义），给药前E90为7.2±2.1J，给药后为8.6±3.3J（无统计学意义）。奎尼丁通过一系列两次负荷及维持输注给药，分别达到平均血浆浓度2.4±0.63和2.95±0.88μg/ml（n = 8）。未观察到对除颤能量需求有显著影响；治疗前后平均E50分别为6.3±3.3J和6.2±2.9J，平均E90分别为8.3±4.4J和8.3±4.1J。同样，给对照犬（n = 12）输注生理盐水后，E50或E90无变化。在与严重心律失常患者相似的浓度或剂量下，在我们的犬模型中，奎尼丁和溴苄铵似乎均对体内除颤的能量需求无一致影响。
