基于无标记磁 SERS 平台的外泌体一体化分离与检测
Integrated separation and detection of exosomes a label-free magnetic SERS platform.
机构信息
College of Chemistry and Materials Science and Analytical & Testing Center, Nanjing Normal University, Nanjing 210023, China.
Department of Pharmaceutical Analysis, China Pharmaceutical University, Nanjing 211198, China.
出版信息
Chem Commun (Camb). 2023 Jun 22;59(51):7967-7970. doi: 10.1039/d3cc01530k.
A label-free magnetic surface enhanced Raman scattering (SERS) platform was constructed, which was composed of superparamagnetic FeO nanoparticles as cores for separation and Au layers as shells for label-free SERS detection. Our method could effectively distinguish exosomes from different cell sources for cancer diagnosis and showed high sensitivity and specificity within a 95% confidence interval. As a low-cost and efficient exosome analysis method, the designed integrated platform for separation and detection has promising applicability in clinical diagnostics.
构建了一种无标记的磁性表面增强拉曼散射（SERS）平台，该平台由超顺磁 FeO 纳米粒子作为核心用于分离，以及 Au 层作为用于无标记 SERS 检测的外壳。我们的方法可以有效地从不同细胞来源的外体中进行区分，用于癌症诊断，并在 95%置信区间内显示出高灵敏度和特异性。作为一种低成本、高效率的外体分析方法，所设计的分离和检测集成平台在外体临床诊断中具有广阔的应用前景。
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