Zhou Qing-Qing, Xie Xiao-Yan, Zhang Yan-Xia, Zhou Wu, Zhan Zha-Jun, Xu Jin-Biao
College of Pharmaceutical Science, Zhejiang University of Technology Hangzhou 310014, China College of Medicine, Jiaxing University Jiaxing 314001, China.
College of Medicine, Jiaxing University Jiaxing 314001, China.
Zhongguo Zhong Yao Za Zhi. 2023 May;48(10):2679-2698. doi: 10.19540/j.cnki.cjcmm.20220623.202.
Cytisine derivatives are a group of alkaloids containing the structural core of cytisine, which are mainly distributed in Fabaceae plants with a wide range of pharmacological activities, such as resisting inflammation, tumors, and viruses, and affecting the central nervous system. At present, a total of 193 natural cytisine and its derivatives have been reported, all of which are derived from L-lysine. In this study, natural cytisine derivatives were classified into eight types, namely cytisine type, sparteine type, albine type, angustifoline type, camoensidine type, cytisine-like type, tsukushinamine type, and lupanacosmine type. This study reviewed the research progress on the structures, plant sources, biosynthesis, and pharmacological activities of alkaloids of various types.
金雀花碱衍生物是一类含有金雀花碱结构核心的生物碱，主要分布于豆科植物中，具有广泛的药理活性，如抗炎、抗肿瘤、抗病毒以及影响中枢神经系统等。目前，共报道了193种天然金雀花碱及其衍生物，它们均来源于L-赖氨酸。本研究将天然金雀花碱衍生物分为八类，即金雀花碱型、鹰爪豆碱型、阿尔宾型、狭叶金雀花碱型、卡蒙西定型、类金雀花碱型、筑紫胺型和羽扇豆胺型。本研究综述了各类生物碱的结构、植物来源、生物合成及药理活性的研究进展。
