College of Plant Protection, Fujian Agriculture and Forestry University, Fuzhou, People's Republic of China.
Department of Pharmacy, Fujian Medical University Union Hospital, Fuzhou, People's Republic of China.
Nat Prod Res. 2023 Apr;37(8):1321-1327. doi: 10.1080/14786419.2021.2005591. Epub 2021 Dec 22.
Two new cytisine-like alkaloids, hositisines C () and D (), were isolated from the seeds of along with four known compounds, (-)-tinctorine (), -adenosine (), 2'-deoxyadenosine (), and 7, 2', 4'-trihydroxy-5-methoxyisoflavanone (). Their structures were established using extensive spectroscopic techniques (UV, IR, CD, HRESIMS, 1 D and 2 D NMR). In the cytotoxic activity, compounds - and 5-fluorouracil (positive control) displayed inhibitory effects against HepG2 cells, exhibiting IC values of 44.52 ± 7.83 μM, 111.49 ± 12.76 μM, 127.72 ± 18.67 μM, and 16.37 ± 3.82 μM.
从 种子中分离得到了两个新的野靛碱样生物碱，hositisines C () 和 D ()，以及四个已知化合物，(-)- 小檗红碱 ()、- 腺苷 ()、2'-脱氧腺苷 () 和 7, 2', 4'-三羟基-5-甲氧基异黄酮 ()。它们的结构通过广泛的光谱技术（UV、IR、CD、HRESIMS、1D 和 2D NMR）确定。在细胞毒性活性中，化合物 - 和 5-氟尿嘧啶（阳性对照）对 HepG2 细胞表现出抑制作用，其 IC 值分别为 44.52 ± 7.83 μM、111.49 ± 12.76 μM、127.72 ± 18.67 μM 和 16.37 ± 3.82 μM。
