Liu Dan, Jia Xiaobin, Yu Danhong, Zhang Zhenhai, Sun E
Key Laboratory of New Drug Delivery System of Chinese Meteria Medica, Jiangsu Provincial Academy of Chinese Medicine, Nanjing 210028, China.
Zhongguo Zhong Yao Za Zhi. 2012 Aug;37(15):2338-43.
With the development of the modernization drive of traditional Chinese medicine (TCM) preparations, new-type TCM dosage forms research have become a hot spot in the field. Because of complexity of TCM components as well as uncertainty of material base, there is still not a scientific system for modern TCM dosage forms so far. Modern TCM preparations inevitably take the nature of the multi-component and the general function characteristics of multi-link and multi-target into account. The author suggests building a multiple drug release system for TCM using diverse preparation techniques and drug release methods at levels on the basis the nature and function characteristics of TCM components. This essay expounds elaborates the ideas to build the multiple traditional Chinese medicine release system, theoretical basis, preparation techniques and assessment system, current problems and solutions, in order to build a multiple TCM release system with a view of enhancing the bioavailability of TCM components and provide a new form for TCM preparations.
随着中药制剂现代化进程的发展,新型中药剂型的研究已成为该领域的热点。由于中药成分的复杂性以及物质基础的不确定性,迄今为止,现代中药剂型仍未形成科学的体系。现代中药制剂不可避免地要考虑多成分的性质以及多环节、多靶点的整体功能特点。作者建议根据中药成分的性质和功能特点,在不同层面采用多种制备技术和释药方法构建中药多释药系统。本文阐述了构建中药多释药系统的思路、理论基础、制备技术与评价体系、现存问题及解决方法,以期构建一个提高中药成分生物利用度的中药多释药系统,为中药制剂提供新的剂型。