Department of Otolaryngology Head and Neck Surgery and Center of Sleep Medicine, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Department of Otolaryngology Head and Neck Surgery, Shanghai Children's Hospital, Shanghai Jiao Tong University, Shanghai, China.
Front Immunol. 2023 May 22;14:1186258. doi: 10.3389/fimmu.2023.1186258. eCollection 2023.
Adenoid hypertrophy is the main cause of obstructive sleep apnea in children. Previous studies have suggested that pathogenic infections and local immune system disorders in the adenoids are associated with adenoid hypertrophy. The abnormalities in the number and function of various lymphocyte subsets in the adenoids may play a role in this association. However, changes in the proportion of lymphocyte subsets in hypertrophic adenoids remain unclear.
To identify patterns of lymphocyte subsets in hypertrophic adenoids, we used multicolor flow cytometry to analyze the lymphocyte subset composition in two groups of children: the mild to moderate hypertrophy group (n = 10) and the severe hypertrophy group (n = 5).
A significant increase in naïve lymphocytes and a decrease in effector lymphocytes were found in severe hypertrophic adenoids.
This finding suggests that abnormal lymphocyte differentiation or migration may contribute to the development of adenoid hypertrophy. Our study provides valuable insights and clues into the immunological mechanism underlying adenoid hypertrophy.
腺样体肥大是儿童阻塞性睡眠呼吸暂停的主要原因。既往研究提示，腺样体的病原感染和局部免疫系统紊乱与腺样体肥大有关，腺样体中各种淋巴细胞亚群数量和功能的异常可能在其中发挥作用，但肥大腺样体中淋巴细胞亚群比例的变化尚不清楚。
为明确腺样体肥大中淋巴细胞亚群的变化模式，我们采用多色流式细胞术分析了两组儿童的淋巴细胞亚群组成，其中轻度至中度肥大组（n = 10）和重度肥大组（n = 5）。
重度肥大的腺样体中发现幼稚淋巴细胞显著增加，效应淋巴细胞减少。
这一发现提示异常的淋巴细胞分化或迁移可能导致腺样体肥大的发生。本研究为腺样体肥大的免疫学发病机制提供了有价值的见解和线索。
