Ng Choon Ta, Gonzalez Bonilla Hilda M, Chang Ian, Aung M Tun, Gile Jennifer J, Pereira Naveen L, Villasboas Bisneto Jose C, Johnston Patrick B, Villarraga Hector R, Rodriguez-Porcel Martin G, Lin Grace, Lin Yi, Herrmann Joerg
Department of Cardiovascular Medicine, Mayo Clinic Rochester, Rochester, Minnesota, USA.
Department of Cardiology, National Heart Centre Singapore.
JACC Case Rep. 2023 Apr 21;15:101840. doi: 10.1016/j.jaccas.2023.101840. eCollection 2023 Jun 7.
Chimeric antigen receptor T-cell (CAR-T) therapy has revolutionized the management of aggressive hematologic malignancies. However, its role in patients with lymphoma and cardiac metastasis or cardiomyopathy remains undefined due to potentially life-threatening complications such as ventricular rupture, cardiac tamponade, and circulatory failure. We present a case series of patients with lymphoma and cardiomyopathy or cardiac metastasis managed with chimeric antigen receptor T-cell therapy. ().
嵌合抗原受体T细胞（CAR-T）疗法彻底改变了侵袭性血液系统恶性肿瘤的治疗方式。然而，由于存在诸如心室破裂、心脏压塞和循环衰竭等潜在危及生命的并发症，其在淋巴瘤合并心脏转移或心肌病患者中的作用仍不明确。我们报告了一组采用嵌合抗原受体T细胞疗法治疗的淋巴瘤合并心肌病或心脏转移患者的病例系列。（）
