Xiao Dan, Yan Changxiang, Li Deling, Xi Tianshu, Liu Xianzhi, Zhu Dan, Huang Guodong, Xu Jianguo, He Zhengwen, Wu Anhua, Ma Chiyuan, Long Jiang, Shu Kai, Ji Hongming, Wang Ning, Chen Gang, Yang Jiankai, Ma Hui, Li Zhiyong, Sun Xiaochuan, Qu Yan, Liu Zhixiong, Jiang Xiaofan, Tian Chunlei, Ni Shilei, Zhan Renya, Chen Liwen, Ge Ming, Wang Maode, Jiang Xiaobing, Guo Geng, Han Zhenmin, Zhang Chuan, Zhang Tingrong, Dou Changwu, Chu Liangzhao, Wang Pengcheng, Shao Junfei, Wu Xiyue, Yu Ju, Wang Yu, Wu Nan, Zhang Rui, Zhang Mingming, Hong Yong, Gao Jianzhong, Li Yunqian, Pan Yawen, Zhao Bing, Ji Nan, Shan Guangliang, Patel Chirag B, Jia Wang, Zhang Liwei
China National Clinical Research Center for Neurological Diseases (NCRC-ND), Beijing, China.
Department of Neurosurgery, Sanbo Brain Hospital, Capital Medical University, Beijing, China.
Lancet Reg Health West Pac. 2023 Feb 21;34:100715. doi: 10.1016/j.lanwpc.2023.100715. eCollection 2023 May.
The lack of a well-designed brain tumour registry with standardized pathological diagnoses in underdeveloped countries hinders the ability to compare epidemiologic data across the globe. The National Brain Tumour Registry of China (NBTRC), created in January 2018, is the first multi-hospital-based brain tumour registry in China. Patient data reported to the NBTRC in years 2019-2020 were assessed.
Tumour pathology was based on the 2016 World Health Organization (WHO) classification of tumours of the central nervous system and ICD-O-3. The anatomical site was coded per the Surveillance, Epidemiology, and End Results (SEER) solid tumour module (version of July 2019). The cases were tabulated by histology and anatomical site. Categorical variables were reported as numbers (percentages). The distribution of tumours by age (0-14, 15-19, 20-39, 40-64, and 65+ years) was analysed.
There were a total of 25,537 brain tumours, foremost among them meningioma (23.63%), followed by tumours of the pituitary (23.42%), and nerve sheath tumours (9.09%). Glioblastoma, the most common and lethal form of primary brain cancer in adults, represented 8.56% of all cases. Of note, 6.48% of the malignant tumours were located in the brain stem. The percentage of malignant brain tumours decreased with increasing age, 24.08% in adults (40+ years), 30.25% in young adults (20-39 years), 35.27% in adolescents (15-19 years), and 49.83% in children (0-14 years). Among the 2107 paediatric patients, the most common sites were ventricle (17.19%), brainstem (14.03%), pituitary and craniopharyngeal duct (13.4%), and cerebellum (12.3%), a distribution that differed from that of the entire cohort. The histology distribution was also unique in children, with glioblastoma much less incident compared to the whole cohort (3% vs. 8.47%, < 0.01). 58.80% of all patients chose higher-level neurosurgical hospitals outside of their province of residence. The median in-hospital length of stay (LOS) for the various pathologies ranged from 11 to 19 days.
The histological and anatomical site distribution of brain tumours in the NBTRC was statistically different in the subgroup of children (0-14 years). Patient choice of pursuing trans-provincial treatment was common and the in-hospital LOS was longer compared to that reported in similar European and American patient populations, which merits further attention.
The National Key Research and Development Program of China (2015BAI12B04, 2013BAI09B03, 2014BAI04B01, and 2021YFF1201104) and Chinese National Natural Science Foundation of China (81971668).
在欠发达国家，缺乏设计良好且具备标准化病理诊断的脑肿瘤登记系统，这阻碍了全球范围内流行病学数据的比较。中国国家脑肿瘤登记中心（NBTRC）于2018年1月成立，是中国首个多医院基础的脑肿瘤登记中心。对2019 - 2020年向NBTRC报告的患者数据进行了评估。
肿瘤病理学基于2016年世界卫生组织（WHO）中枢神经系统肿瘤分类和ICD - O - 3。解剖部位按照监测、流行病学和最终结果（SEER）实体瘤模块（2019年7月版本）进行编码。病例按组织学和解剖部位列表。分类变量以数字（百分比）形式报告。分析了肿瘤按年龄（0 - 14岁、15 - 19岁、20 - 39岁、40 - 64岁和65岁以上）的分布情况。
共有25537例脑肿瘤，其中最常见的是脑膜瘤（23.63%），其次是垂体肿瘤（23.42%）和神经鞘瘤（9.09%）。胶质母细胞瘤是成人中最常见且致命的原发性脑癌形式，占所有病例的8.56%。值得注意的是，6.48%的恶性肿瘤位于脑干。恶性脑肿瘤的百分比随年龄增长而降低，成人（40岁以上）为24.08%，青年成人（20 - 39岁）为30.25%，青少年（15 - 19岁）为35.27%，儿童（0 - 14岁）为49.83%。在2107例儿科患者中，最常见的部位是脑室（17.19%）、脑干（14.03%）、垂体和颅咽管（13.4%）以及小脑（12.3%），这种分布与整个队列不同。儿童的组织学分布也很独特，与整个队列相比，胶质母细胞瘤的发病率要低得多（3%对8.47%，<0.01）。所有患者中有58.80%选择了省外更高水平的神经外科医院。各种病理类型的住院中位时长为11至19天。
NBTRC中脑肿瘤的组织学和解剖部位分布在儿童（0 - 14岁）亚组中存在统计学差异。患者选择跨省治疗很常见，且住院时长比欧美类似患者群体报告的更长，这值得进一步关注。
中国国家重点研发计划（2015BAI12B04、2013BAI09B03、2014BAI04B01和2021YFF1201104）以及中国国家自然科学基金（81971668）。
