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一例伴有血尿和低补体水平的孤立性肾轻链淀粉样变性病例。

A Case of Isolated Renal Light Chain Amyloidosis With Hematuria and Low Complement Levels.

作者信息

Javed Nismat, Uday Kalpana

机构信息

Internal Medicine, BronxCare Health System, New York City, USA.

Nephrology, BronxCare Health System, New York CIty, USA.

出版信息

Cureus. 2023 May 5;15(5):e38572. doi: 10.7759/cureus.38572. eCollection 2023 May.

Abstract

The prevalence of light chain (AL) amyloidosis, characterized by the deposition of amyloid chains, is gradually increasing. The clinical features of the disease depend upon the location of amyloid deposition and can manifest in many forms. Although laboratory investigations can reveal proteinuria and change in complement levels, hematuria and low complement levels are rarely reported. There are very few cases of renal AL amyloidosis presenting as persistent hematuria. We present the case of a 54-year-old female presenting with abdominal pain, proteinuria, and moderate persistent hematuria on admission who was later diagnosed with AL amyloidosis on biopsy.

摘要

以淀粉样蛋白链沉积为特征的轻链(AL)淀粉样变性的患病率正在逐渐上升。该疾病的临床特征取决于淀粉样蛋白沉积的位置,可表现为多种形式。尽管实验室检查可发现蛋白尿和补体水平变化,但血尿和低补体水平的报道很少。很少有肾AL淀粉样变性表现为持续性血尿的病例。我们报告一例54岁女性病例,入院时表现为腹痛、蛋白尿和中度持续性血尿,活检后被诊断为AL淀粉样变性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/386b/10239556/a7f4845b0b3e/cureus-0015-00000038572-i01.jpg

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