Melton L J, Wahner H W, Richelson L S, O'Fallon W M, Riggs B L
Am J Epidemiol. 1986 Aug;124(2):254-61. doi: 10.1093/oxfordjournals.aje.a114383.
The incidence of cervical and intertrochanteric proximal femur fractures at various levels of cervical and intertrochanteric bone mineral density, respectively, was estimated by using population-based data from ongoing studies of osteoporosis and fractures among women residing in Rochester, Minnesota. Hip fractures were uncommon among women with femoral bone density greater than or equal to 1.0 g/cm2, but their frequency increased as bone density declined below that point at both femoral sites. The incidence of cervical femur fractures was estimated at 8.3 per 1,000 person-years among women with cervical bone density less than 0.6 g/cm2, while the estimated incidence of intertrochanteric femur fractures reached 16.6 per 1,000 person-years among those with intertrochanteric bone density less than 0.6 g/cm2. This new approach to the assessment of fracture risk from bone mineral density measurements indicates that osteoporosis is an important underlying cause of hip fractures.
利用明尼苏达州罗切斯特市正在进行的一项关于骨质疏松症和骨折的研究中基于人群的数据，分别估算了不同水平的颈椎和股骨转子间骨密度下颈椎和股骨转子间近端股骨骨折的发生率。股骨骨密度大于或等于1.0g/cm²的女性中髋部骨折并不常见，但在两个股骨部位，随着骨密度降至该点以下，其发生频率增加。颈椎骨密度低于0.6g/cm²的女性中，颈椎股骨骨折的发生率估计为每1000人年8.3例，而转子间骨密度低于0.6g/cm²的女性中，转子间股骨骨折的估计发生率达到每1000人年16.6例。这种通过骨密度测量评估骨折风险的新方法表明，骨质疏松症是髋部骨折的一个重要潜在原因。
