Cruz-Aragón Guillermo, Márquez Manlio F, Cueva-Parra Angel, González-Pacheco Héctor, Iturralde Pedro, Nava Santiago
Departamento de Electrofisiología, Instituto Nacional de Cardiología Ignacio Chávez. Ciudad de México, México. Departamento de Electrofisiología, Instituto Nacional de Cardiología Ignacio Chávez Ciudad de México México.
Unidad Coronaria, Instituto Nacional de Cardiología Ignacio Chávez. Ciudad de México, México. Unidad Coronaria, Instituto Nacional de Cardiología Ignacio Chávez Ciudad de México México.
Arch Peru Cardiol Cir Cardiovasc. 2022 Sep 30;3(3):132-138. doi: 10.47487/apcyccv.v3i2.223.. eCollection 2022 Jul-Sep.
The Global Registry of Acute Coronary Events (GRACE) prediction model stratifies patients with non-ST-segment elevation myocardial infarction (NSTEMI). Corrected QT interval (QTc) is not considered in this model.
To evaluate the relationship between the QTc interval and the GRACE score in patients with NSTEMI.
An observational, retrospective study was carried between 2016 and 2019. We included patients with diagnosis of NSTEMI, QTc intervals were calculated with Bazett's formula, and they were classified into 2 groups: a normal QTc interval (<440 ms) and prolonged (≥440 ms). According to the GRACE score they were classified in three ranges: low risk (≤109 points), intermedium (110 - 139 points) and high (≥140 points), we determined if there were a correlation between QTc interval and the GRACE score.
A total of 940 patients with a diagnosis of NSTEMI were admitted in our institution, 634 met the inclusion criteria, there were 390 patients with normal QTc interval and 244 with a prolonged QTc interval. Patients with prolonged QTc were older (65.5 vs 61, p=0.001) with a lower proportion of males (71.7% vs 82.8%, p=0.001). An association was found between the GRACE score and the QTC interval, subjects with a normal QTc had a greater proportion of low and intermediate risk than those with a prolonged QTc (p=0.001). In NSTEMI patients, a normal QTc interval (<440 ms) is associated with a GRACE risk score of low or intermediate risk.
全球急性冠状动脉事件注册研究（GRACE）预测模型对非ST段抬高型心肌梗死（NSTEMI）患者进行分层。该模型未考虑校正QT间期（QTc）。
评估NSTEMI患者QTc间期与GRACE评分之间的关系。
于2016年至2019年开展一项观察性回顾性研究。纳入诊断为NSTEMI的患者，采用Bazett公式计算QTc间期，并将其分为两组：正常QTc间期（<440毫秒）和延长QTc间期（≥440毫秒）。根据GRACE评分将患者分为三个范围：低风险（≤109分）、中风险（110 - 139分）和高风险（≥140分），我们确定QTc间期与GRACE评分之间是否存在相关性。
我院共收治940例诊断为NSTEMI的患者，634例符合纳入标准，其中390例患者QTc间期正常，244例患者QTc间期延长。QTc间期延长的患者年龄较大（65.5岁对61岁，p = 0.001），男性比例较低（71.7%对82.8%，p = 0.001）。发现GRACE评分与QTc间期之间存在关联，QTc正常的受试者低风险和中风险的比例高于QTc延长的受试者（p = 0.001）。在NSTEMI患者中，正常QTc间期（<440毫秒）与低风险或中风险的GRACE风险评分相关。
