Steno Diabetes Center Aarhus, Aarhus University Hospital, Aarhus, Denmark.
Department of Clinical Medicine, University of Aarhus, Aarhus, Denmark.
J Pediatr Endocrinol Metab. 2023 Jun 8;36(7):643-649. doi: 10.1515/jpem-2023-0228. Print 2023 Jul 26.
The prevalence of childhood obesity increases globally, and noninvasive methods are needed to identify metabolic dysfunction and obesity-related complications such as pediatric metabolic associated fatty liver disease (MAFLD). We investigated whether uric acid (UA) and the macrophage marker soluble form of cysteine scavenger receptor CD163 (sCD163) can be used as biomarkers for deteriorated metabolism or pediatric MAFLD in children with overweight or obesity.
Cross-sectional clinical and biochemical data from 94 children with overweight or obesity was included. Surrogate liver markers were calculated, and correlations were investigated using Pearson's or Spearman's correlation test.
UA and sCD163 correlated with BMI standard deviation score (r=0.23, p<0.05; r=0.33, p<0.01) and body fat (r=0.24, p<0.05; r=0.27, p=0.01). UA correlated with triglycerides (ρ=0.21, p<0.05), fat free mass (r=0.33, p<0.01), and gamma-glutamyl transferase (r=0.39, p<0.01). sCD163 correlated with the pediatric NAFLD fibrosis score (r=0.28, p<0.01) and alanine aminotransferase (r=0.28, p<0.01). No correlation was found between UA and pediatric MAFLD.
UA and sCD163 was identified as markers of a deranged metabolic profile, thus acting as easily accessible biomarkers for obesity and an obesity-related deranged metabolism. Furthermore, increasing levels of sCD163 could be a useful biomarker of pediatric MAFLD. Future prospective studies are warranted.
儿童肥胖症的患病率在全球范围内不断增加，因此需要采用非侵入性方法来识别代谢功能障碍和肥胖相关并发症，如儿科代谢相关脂肪性肝病（MAFLD）。我们研究了尿酸（UA）和巨噬细胞标志物可溶性半胱氨酸清除受体 CD163（sCD163）是否可以作为超重或肥胖儿童代谢恶化或儿科 MAFLD 的生物标志物。
纳入了 94 名超重或肥胖儿童的横断面临床和生化数据。计算了替代肝标志物，并使用 Pearson 或 Spearman 相关检验来研究相关性。
UA 和 sCD163 与 BMI 标准差评分（r=0.23，p<0.05；r=0.33，p<0.01）和体脂肪（r=0.24，p<0.05；r=0.27，p=0.01）相关。UA 与甘油三酯（ρ=0.21，p<0.05）、去脂体重（r=0.33，p<0.01）和γ-谷氨酰转移酶（r=0.39，p<0.01）相关。sCD163 与儿科 NAFLD 纤维化评分（r=0.28，p<0.01）和丙氨酸氨基转移酶（r=0.28，p<0.01）相关。UA 与儿科 MAFLD 无相关性。
UA 和 sCD163 被确定为代谢谱紊乱的标志物，因此可作为肥胖和肥胖相关代谢紊乱的易于获取的生物标志物。此外，sCD163 水平升高可能是儿科 MAFLD 的有用生物标志物。需要进一步的前瞻性研究。
