2型糖尿病合并脂肪肝患者血清尿酸水平与肝脏硬度的关系。
The relationship between serum uric acid levels and liver stiffness in patients with type II diabetes mellitus and fatty liver disease.
作者信息
Yakut Aysun
机构信息
Istanbul Medipol University, Sefakoy Hospital, Health Application and Research Center, Department of Gastroenterology - İstanbul, Türkiye.
出版信息
Rev Assoc Med Bras (1992). 2024 Dec 16;70(12):e20241013. doi: 10.1590/1806-9282.20241013. eCollection 2024.
OBJECTIVE
High serum uric acid levels are associated with metabolic syndrome and diabetes mellitus. Several observational studies have shown the association between metabolic dysfunction-associated fatty liver disease and high serum uric acid. However, this association is controversial due to reverse causality. We aimed to investigate the relationship between the serum uric acid level and "aspartate aminotransferase-platelet ratio index score," which noninvasively shows the possible changes of metabolic dysfunction-associated fatty liver disease in the liver in patients diagnosed with type II diabetes mellitus.
METHODS
This retrospective study was conducted with a total of 94 patients, 36 females and 58 males, who were hospitalized in the gastroenterohepatology outpatient clinic and diagnosed with hepatosteatosis and type II diabetes mellitus between January 2023 and January 2024. Laboratory tests, height, weight, body mass index, presence of fatty liver disease on ultrasound, and aspartate aminotransferase-platelet ratio index scores of the patients were examined.
RESULTS
The mean serum uric acid level of the patients was 5.26±1.52 mg/dL, and the mean aspartate aminotransferase-platelet ratio index score was 0.26±0.13. The serum uric acid level was found to be associated with the hemoglobin A1c value (p=0.001; p<0.01). However, the aspartate aminotransferase-platelet ratio index scores of the patients did not show a statistically significant difference according to serum uric acid levels (p>0.05).
CONCLUSION
No significant association was observed between serum uric acid and the noninvasive liver test aspartate aminotransferase-platelet ratio index score. Although a causal relationship between metabolic dysfunction-associated fatty liver disease and serum uric acid has been demonstrated in several studies, further research is needed to evaluate possible mechanisms in the liver.
目的
高血清尿酸水平与代谢综合征和糖尿病相关。多项观察性研究显示了代谢功能障碍相关脂肪性肝病与高血清尿酸之间的关联。然而，由于反向因果关系，这种关联存在争议。我们旨在研究血清尿酸水平与“天冬氨酸转氨酶 - 血小板比值指数评分”之间的关系，该评分可无创显示2型糖尿病患者肝脏中代谢功能障碍相关脂肪性肝病的可能变化。
方法
本回顾性研究共纳入94例患者，其中女性36例，男性58例，于2023年1月至2024年1月在胃肠肝病门诊住院，诊断为肝脂肪变性和2型糖尿病。检查了患者的实验室检查、身高、体重、体重指数、超声检查中脂肪肝的存在情况以及天冬氨酸转氨酶 - 血小板比值指数评分。
结果
患者的平均血清尿酸水平为5.26±1.52mg/dL，平均天冬氨酸转氨酶 - 血小板比值指数评分为0.26±0.13。发现血清尿酸水平与糖化血红蛋白值相关（p = 0.001；p<0.01）。然而，根据血清尿酸水平，患者的天冬氨酸转氨酶 - 血小板比值指数评分未显示出统计学上的显著差异（p>0.05）。
结论
血清尿酸与无创肝脏检查天冬氨酸转氨酶 - 血小板比值指数评分之间未观察到显著关联。尽管多项研究已证明代谢功能障碍相关脂肪性肝病与血清尿酸之间存在因果关系，但仍需要进一步研究来评估肝脏中的可能机制。
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