Thatcher C D, Keith J C
Am J Obstet Gynecol. 1986 Jul;155(1):201-7. doi: 10.1016/0002-9378(86)90111-0.
Selected hemodynamic, renal, and biochemical parameters were assessed in chronically instrumented third-trimester pregnant ewes and in the same ewes after induction of pregnancy toxemia. Ewes with induced pregnancy toxemia developed hypertension, proteinuria, ketonuria, decreased glomerular filtration rate, decreased cardiac output, and decreased left uterine artery blood flow. Histological and transmission electron microscopy revealed the development of renal morphologic changes consistent with those observed in human pregnancy-induced hypertension. These studies have elucidated that pregnancy-induced hypertension can be produced experimentally in the pregnant ewe. Furthermore, the pathophysiologic features of ovine pregnancy toxemia are similar to those of human preeclampsia, and therefore the sheep provides a suitable animal model to study the human condition, which still remains a major complication of pregnancy, jeopardizing both mother and fetus.
对长期植入监测仪器的妊娠晚期母羊以及诱发妊娠毒血症后的同一批母羊，评估了选定的血流动力学、肾脏和生化参数。诱发妊娠毒血症的母羊出现了高血压、蛋白尿、酮尿、肾小球滤过率降低、心输出量减少以及左子宫动脉血流量减少。组织学和透射电子显微镜检查显示，肾脏形态学变化的发展与人类妊娠高血压中观察到的变化一致。这些研究阐明了妊娠高血压可在妊娠母羊中通过实验诱发。此外，绵羊妊娠毒血症的病理生理特征与人类先兆子痫相似，因此绵羊为研究这种仍然是妊娠主要并发症、危及母婴的人类疾病提供了合适的动物模型。
