Urbanski S J, Haber G, Hartwick W, Kortan P, Marcon N, Miceli P
Am J Pathol. 1986 Jul;124(1):34-8.
In order to assess the presence of morphologically recognizable colonic nonneoplastic mucosal alterations that may be associated with adenomatous transformation the authors undertook a retrospective analysis of 984 colonic polyps removed between 1979 and 1983. There were 708 adenomatous and 276 nonadenomatous polyps, all colonoscopically removed. In addition to adenomatous mucosa, three different mucosal patterns were recognized and labeled as transitional, eosinophilic, and, hyperplastic. Each polyp, but not the polyp's shoulder, was scored by two pathologists for the presence of these changes. Analysis of the data (Pearson's chi-square test) demonstrated a strong association between eosinophilic and transitional mucosa as well as between eosinophilic mucosa and adenomas. There was also a strong negative association between both eosinophilic and transitional mucosa and hyperplastic mucosa. On the basis of these data, it is postulated that transitional mucosa, representing a nonspecific reactive mucosal phenomenon, may precede eosinophilic mucosa, which subsequently may represent fertile soil for adenomatous transformation.
为了评估可能与腺瘤性转化相关的形态学上可识别的结肠非肿瘤性黏膜改变的存在情况，作者对1979年至1983年间切除的984个结肠息肉进行了回顾性分析。其中有708个腺瘤性息肉和276个非腺瘤性息肉，均通过结肠镜切除。除腺瘤性黏膜外，还识别出三种不同的黏膜模式，并分别标记为移行性、嗜酸性和增生性。两名病理学家对每个息肉（而非息肉的基底部）是否存在这些改变进行评分。数据分析（Pearson卡方检验）表明，嗜酸性黏膜与移行性黏膜之间以及嗜酸性黏膜与腺瘤之间存在密切关联。嗜酸性黏膜和移行性黏膜与增生性黏膜之间也存在强烈的负相关。基于这些数据，推测移行性黏膜作为一种非特异性反应性黏膜现象，可能先于嗜酸性黏膜出现，而嗜酸性黏膜随后可能是腺瘤性转化的沃土。
