Tseng C C, Johnson L R
Am J Physiol. 1986 Jul;251(1 Pt 1):G111-6. doi: 10.1152/ajpgi.1986.251.1.G111.
The role of thyroxine (T4) on the functional development of chief and parietal cells was studied in the rat. Daily injection of thyroxine (0.1 microgram/g body wt) resulted in the precocious appearance of pepsinogen in the oxyntic gland mucosa and an increase in basal acid output. Thyroxine had no effect in adrenalectomized rats. In propylthiouracil-induced hypothyroid pups, pepsinogen content and basal acid secretion were low. Corticosterone acetate (200 micrograms/g body wt) injection increased pepsinogen content and basal acid secretion in the absence of normal levels of thyroid hormones. We conclude that the effect of thyroxine on the development of chief and parietal cells is primarily due to accompanying changes in serum corticosterone.
在大鼠中研究了甲状腺素（T4）对主细胞和壁细胞功能发育的作用。每日注射甲状腺素（0.1微克/克体重）导致胃底腺黏膜中胃蛋白酶原过早出现，基础酸分泌增加。甲状腺素对肾上腺切除的大鼠没有影响。在丙硫氧嘧啶诱导的甲状腺功能减退幼崽中，胃蛋白酶原含量和基础酸分泌较低。注射醋酸皮质酮（200微克/克体重）在缺乏正常水平甲状腺激素的情况下增加了胃蛋白酶原含量和基础酸分泌。我们得出结论，甲状腺素对主细胞和壁细胞发育的影响主要是由于血清皮质酮的伴随变化。
