Centro de Investigacion Biomedica, Universidad Autonoma de Coahuila, Unidad Torreon, Torreon, Mexico.
Facultad de Medicina, Universidad Autonoma de Coahuila, Unidad Torreon, Torreón, Mexico.
Sci Rep. 2023 Jun 7;13(1):9244. doi: 10.1038/s41598-023-36166-5.
Chronic endemic regional hydroarsenicism (CERHA) is a global issue that affects over 200 million people exposed to arsenic (As) in drinking water. This includes 1.75 million individuals residing in La Comarca Lagunera, a region in north-central Mexico. Arsenic levels in this region typically exceeds the WHO guideline of 10 µg L. Biochemical alterations related to the human As metabolism may increase the risk of overweight and obesity (O&O), type 2 diabetes (T2D), and hypertension (AHT). In our study, we investigated the role of As in drinking water as a risk factor for these metabolic diseases. We focused on populations with historically moderate (San Pedro) and low (Lerdo) drinking water As levels and people with no historical evidence of As water contamination. The exposure assessment to As was based on measurements of the drinking water (medians 67.2, 21.0, 4.3 µg L) and urinary As concentrations in women (9.4, 5.3, 0.8 µg L) and men (18.1, 4.8, 1.0 µg L). A significant correlation between As in drinking water and urine evidenced the As exposure in the population (R = 0.72). Adjusted odds ratios with 95% confidence intervals evidenced higher chances of being diagnosed with T2D (1.7, 1.2-2.0) and AHT (1.8, 1.7-1.9) in individuals living in San Pedro than those in Lerdo. Still, there was no significant association with obesity. Individuals living in CERHA towns were found to have a higher risk of obesity (1.3-1.9), T2D (1.5 to 3.3), and AHT (1.4 to 2.4) compared to those residing in non-CERHA towns. Finally, obesity is more probable in women [inverse of OR and 95%CI 0.4 (0.2-0.7)] compared to men, while men is more likely to be diagnosed with T2D [OR = 2.0 (1.4-2.3)] and AHT [OR = 2.0 (1.5-2.3)] than women, independently of the municipality.
慢性地方性区域性砷中毒（CERHA）是一个全球性问题，影响着超过 2 亿暴露于饮用水中砷（As）的人群。这其中包括居住在墨西哥中北部拉科马拉加内拉地区的 175 万人。该地区的砷含量通常超过世界卫生组织规定的 10μg/L。与人类砷代谢相关的生化变化可能会增加超重和肥胖（O&O）、2 型糖尿病（T2D）和高血压（AHT）的风险。在我们的研究中，我们调查了饮用水中砷作为这些代谢性疾病的危险因素的作用。我们专注于具有历史上中等（圣佩德罗）和低（莱尔多）饮用水砷水平的人群以及没有历史砷水污染证据的人群。砷暴露评估基于妇女饮用水（中位数 67.2、21.0、4.3μg/L）和尿液中砷浓度的测量值以及男子（18.1、4.8、1.0μg/L）。饮用水和尿液中砷含量之间存在显著相关性，证明了人群中的砷暴露（R=0.72）。调整后的 95%置信区间比值比表明，与莱尔多相比，居住在圣佩德罗的个体患 T2D（1.7，1.2-2.0）和 AHT（1.8，1.7-1.9）的几率更高。然而，与肥胖没有显著关联。与居住在非 CERHA 城镇的个体相比，居住在 CERHA 城镇的个体更容易出现肥胖（1.3-1.9）、T2D（1.5-3.3）和 AHT（1.4-2.4）。最后，与男性相比，女性更容易肥胖[比值比和 95%置信区间的倒数 0.4（0.2-0.7）]，而男性更有可能被诊断为 T2D[比值比 2.0（1.4-2.3）]和 AHT[比值比 2.0（1.5-2.3）]，而不论其所在的城镇如何。
