Additional Professor, Department of Pediatrics, Government Medical College, Kozhikode, Kerala, India.
Professor, Department of Pediatrics, Government Medical College, Kozhikode, Kerala, India.
Trop Doct. 2023 Oct;53(4):509-511. doi: 10.1177/00494755231180004. Epub 2023 Jun 7.
We report three sporadic infections by from Government Medical College Kozhikode in Kerala state, South India over a period of three years. Two cases were commenced in the community in immunocompromised children beyond the newborn period, but both recovered promptly. Another was a hospital-acquired meningitis in a newborn baby who developed neurologic sequelae. In contrast to widespread antimicrobial resistance exhibited by this pathogen, there was good susceptibility to commonly used antimicrobials such as ampicillin, cefotaxime, piperacillin, ciprofloxacin, and vancomycin. Whilst ß lactam antibiotics are found effective in the treatment of septicaemia of children, piperacillin-tazobactam, vancomycin combination seems effective empiric choice of antibiotics for neonatal meningitis due to there is a need for guidelines for the management of this infection, especially in neonatal meningitis.
我们报道了印度南部喀拉拉邦政府医学院科泽科德三年内发生的三例由 引起的散发性感染。两例发生在免疫功能低下的新生儿期后的社区儿童中,但均迅速康复。另一个是新生儿院内获得性脑膜炎,患儿出现神经系统后遗症。与该病原体表现出的广泛抗菌药物耐药性不同,其对常用抗菌药物如氨苄西林、头孢噻肟、哌拉西林、环丙沙星和万古霉素具有良好的敏感性。虽然β内酰胺类抗生素在治疗儿童败血症方面有效,但哌拉西林-他唑巴坦、万古霉素联合治疗似乎是治疗 引起的新生儿脑膜炎的经验性抗生素选择,因为需要制定针对这种感染的管理指南,特别是在新生儿脑膜炎的情况下。