Metrology Research Centre, National Research Council Canada, Ottawa, Ontario, Canada.
Department of Physics, Carleton University, Ottawa, Ontario, Canada.
Med Phys. 2023 Oct;50(10):6543-6553. doi: 10.1002/mp.16526. Epub 2023 Jun 7.
Electron synchrotrons produce x-ray beams with dose rates orders of magnitude greater than conventional x-ray tubes and with beam sizes on the order of a few millimeters. These characteristics put severe challenges on current dosimeters to accurately realize absorbed dose or air kerma.
This work seeks to investigate the suitability of a novel aluminum-based calorimeter to determine absorbed dose to water with an uncertainty significantly smaller than currently possible with conventional detectors. A lower uncertainty in the determination of absolute dose rate would impact both therapeutic applications of synchrotron-produced x-ray beams and research investigations.
A vacuum-based calorimeter prototype with an aluminum core was built, matching the beam profile of the 140 keV monochromatic x-ray beam, produced by the Canadian Light Source Biomedical Imaging and Therapy beamline. The choice of material and overall calorimeter design was optimized using FEM thermal modeling software while Monte Carlo radiation transport simulations were used to model the impact of interactions of the radiation beam with the detector components.
Corrections for both the thermal conduction and radiation transport effects were of the order of 3% and the simplicity of the geometry, combined with the monochromatic nature of the incident x-ray beam, meant that the uncertainty in each correction was ≤0.5%. The calorimeter performance was found to be repeatable over multiple irradiations of 1 Gy at the ± 0.6% level, and no systematic dependence on environmental effects or total dose was observed.
The combined standard uncertainty in the determination of absorbed dose to aluminum was estimated to be 0.8%, indicating that absorbed dose to water, the ultimate quantity of interest, could be determined with an uncertainty on the order of 1%. This value is an improvement over current techniques used for synchrotron dosimetry and comparable with the state-of-the art for conventional kV x-ray dosimetry.
电子同步加速器产生的 X 射线束的剂量率比传统 X 射线管高出几个数量级,束斑尺寸约为几毫米。这些特性对当前的剂量计提出了严峻的挑战,使其难以准确实现吸收剂量或空气比释动能。
本研究旨在探讨一种新型铝基量热计用于确定水吸收剂量的适用性,其不确定度明显小于传统探测器目前所能达到的水平。在确定绝对剂量率方面的不确定性降低,将对同步加速器产生的 X 射线束的治疗应用和研究调查产生影响。
构建了一个基于真空的铝芯量热计原型,其束斑形状与加拿大光源生物医学成像与治疗光束线产生的 140keV 单色 X 射线束相匹配。材料的选择和整体量热计设计使用有限元热模拟软件进行了优化,而蒙特卡罗辐射输运模拟则用于模拟辐射束与探测器组件相互作用的影响。
热传导和辐射输运效应的修正约为 3%,探测器的几何形状简单,再加上入射 X 射线束的单色性,这意味着每个修正的不确定性都≤0.5%。发现该量热计在多次 1Gy 辐照下的性能具有可重复性,其不确定度在±0.6%的水平,且未观察到与环境效应或总剂量有关的系统依赖性。
确定铝吸收剂量的综合标准不确定度估计为 0.8%,这表明水吸收剂量(最终关注的量)的确定不确定度可以达到 1%左右。与当前用于同步加速器剂量学的技术相比,这一值有所提高,与传统千伏 X 射线剂量学的最新技术水平相当。